Raws li US Food & Drug Administration, muaj ntau txoj kev pheej hmoo ntawm serotonin syndrome los ntawm kev sib txuas ntawm cov kev xaiv serotonin reuptake inhibitors (SSRIs) thiab selective serotonin norepinephrine reuptake inhibitors SSNRIs nrog migraine taub hau tshuaj hu ua triptans.
Kev Xaiv Tsa Tshuaj Txhuam Kom Zoo (Serotonin Reuptake Inhibitors) (SSRIs)
Nws ntseeg hais tias lub hlwb muaj ntau pua hom ntau hom tshuaj xa tuaj (neurotransmitters) uas ua raws li cov neeg sawv cev ntawm cov hlwb sib txawv.
Serotonin yog ib tug neurotransmitter uas yog ib qho tseem ceeb ntawm kev tswj cov ntau yam ntawm lub cev thiab kev xav. Cov kab mob serotonin tsawg tsawg tau txuas rau kev nyuaj siab thiab ntxhov siab.
SSRIs inhibit reuptake ntawm serotonin nyob rau hauv lub hlwb. Kev rov ua dua tshiab yog ib txoj kev uas cov neurotransmitters nyob rau hauv lub hlwb reabsorbed thiab deactivated los yog recycled rau yav tom ntej siv. Qhov no ua rau kev nce qib ntawm serotonin ntau ntau, ua rau muaj kev zoo siab, muaj kev ntxhov siab thiab kev tsis ntseeg ntawm kev ntshai . SSRIs raug xam tias yog kev kho thawj kab rau kev tsis sib haum xeeb thiab muaj xws li:
Xaiv Kom Zoo Cov Tshuaj Serotonin-Norepinephrine Rov Qab Los (SSNRIs)
SSNRIs inhibit reabsorption ntawm serotonin thiab norepinephrine hauv lub hlwb. Norepinephrine yog tshuaj tua kabmob hauv hlwb uas cuam tshuam rau kev pw tsaug zog thiab kev kub ntxhov. Nws ntseeg tau tias nws muaj qhov sib txheeb rau kev sib ntaus sib tua-lossis-kev ntxhov siab.
SSNRIs xws li:
- Cymbalta (duloxetine)
- Effectively, Effective XR (venlafaxine)
Triptans
Triptans yog ib chav kawm ntawm cov tshuaj feem ntau siv los kho migraine lossis kab mob taub hau. Lawv ua raws li serotonin receptors nyob rau hauv lub hlwb, yam li cuam tshuam txog serotonin ntau ntau.
Piv txwv ntawm cov tuaj yeem xam muaj:
- Amerge (naratriptan)
- Axert (almotriptan)
- Frova (frovatriptan)
- Imitrex (sumatriptan)
- Maxalt thiab Maxalt-MLT (rizatriptan)
- Relpax (eletriptan)
- Zomig thiab Zomig ZMT (zolmitriptan)
Ntxiv rau cov tshuaj uas qhia hauv FDA advisory, lwm cov tshuaj muaj feem xyuam nrog kev hloov ntawm serotonin qib siab hauv lub hlwb, ua rau muaj kev pheej hmoo ntawm kev kho mob serotonin.
Tricyclic Antidepressants
Tricyclic antidepressants (TCAs) muaj npe tom qab cov tshuaj "peb voj voos" molecular structure. Ua ntej qhov kev qhia txog SSRIs hauv xyoo 1980s, TCAs yog cov tshuaj xaiv rau kev kho mob ntawm kev nyuaj siab , kev ntxhov siab thiab lwm yam kev ntxhov siab. Cov TCAs kuj tseem siv los kho tej yam mob syndromes thiab lub cev qhuav dej (txaj). Nws ntseeg tias TCAs muaj nuj nqi kom nce qib ntawm norepinephrine thiab serotonin nyob rau hauv lub hlwb.
Piv txwv ntawm TCAs muaj xws li:
- Elavil (amitriptyline)
- Tofranil (imipramine)
- Sinequan (doxepin)
- Anafranil (clomipramine)
Cov tshuaj Monoamine Oxidase (MAOIs)
MAOIs yog ib chav kawm ntawm antidepressants ntseeg tias nce qib ntawm norepinephrine, serotonin thiab dopamine hauv lub hlwb. Lawv yuav pab tau rau kev kho mob ntawm kev nyuaj siab ploj, kev ntxhov siab thiab lwm yam kev ntxhov siab. Vim yog kev phom sij uas muaj kev phom sij nrog qee yam khoom noj, haus dej haus cawv thiab lwm yam tshuaj, MAOIs feem ntau suav hais tias yog kev kho mob kawg.
Piv txwv ntawm MAOIs xws li:
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- Marplan (isocarboxazid)
- Emsam (selegiline)
Lwm yam kev tiv thaiv kab mob Antidepressants
Piv txwv ntawm lwm cov tshuaj tiv thaiv kev noj qab haus huv muaj xws li:
- Wellbutrin (bupropion)
- Desyrel (trazadone)
Lwm Cov Tshuaj Hlwb
- BuSpar (buspirone)
- Eskalith (lithium)
Tshuaj Ntsuam Cov Hniav (Mob Killers)
- Codeine
- Fentanyl
- Tramadol
Tshuaj Kho Mob Antibiyotic / Antiretroviral
- Zyvox (linezolid)
- Norvir (ritonavir)
Tshuaj Noj Tshuaj / Khoom Noj Khoom Haus
- Hypericum Perforatum (St. John's Wort)
- Ginseng / Panax
Txoj Kev Tshuaj
- Amphetamines
- Cocaine
- LSD (lysergic acid diethylamide)
Daim ntawv teev npe no tsis yog yuav tsum ua txhua yam. Kom tsis txhob tuaj yeem ua rau koj muaj peev xwm ntawm kev tsim cov kab mob serotonin syndrome, qhia rau koj tus kws kho mob txog tag nrho cov tshuaj thiab kev noj tshuaj pab koj noj.
Yog tias koj pib muaj cov tsos mob ntawm serotonin syndrome, nrhiav kev kho mob tam sim ntawd.
Qhov chaw:
> Prator, Bettina C. "Serotonin Syndrome." Phau ntawv Journal of Neuroscience Nursing . Lub Plaub Hlis 2006. 38 (2): 102-105.
> US Food and Drug Administration. Muaj Feem Xyuam-Ua Phem rau Serotonin Syndrome nrog kev siv SSRIs los yog SNRIs thiab Triptan Medications. Lub Xya Hli 19, 2006.