Txoj Kev Phem ntawm Serotonin Syndrome nrog Johns Wort Plus Antidepressants
St. John's wort, kev noj zaub mov ntxiv, muaj cov yeeb yam zoo li antidepressants, yog li ntawd nws tsis yog ceeb rau kev kawm tias kev ntxiv ntawm St John lub wort yuav cuam tshuam nrog, los yog ntxiv mus rau, cov nyhuv ntawm ib co tshuaj antidepressant. Cia saib qhov kev siv tshuaj ntsuab no ua haujlwm zoo li cas, yam tshuaj twg yuav muaj tshwm sim, thiab cov tsos mob uas koj xav tau.
Txoj Haujlwm ntawm St. John's Wort Ua Haujlwm Li Cas?
St.
Yauhas lub wort yog qhov khoom noj khoom haus ntxiv uas tau muag los ntawm kev nyuaj siab thiab lwm yam mob. Nws tau xav hais tias St. John lub wort yuav siv nws cov nyhav los ntawm kev ua rau cov kab mob hauv serotonin ntau dua . Serotonin yog ib tug neurotransmitter (lub teeb liab ntawm lub hlwb) uas tau pom tias tsis muaj kev tiv thaiv qee cov neeg muaj kev nyuaj siab.
Kev ua rau kom serotonin ntau dua yuav ua rau tsis muaj kev nyuaj siab ntau, tab sis yog hais tias cov qib serotonin ntau dhau muaj qhov mob hu ua serotonin syndrome yuav tshwm sim. Qhov mob no tuaj yeem ua rau mob hnyav heev, thiab txhua tus uas siv antidepressant los yog khoom noj haus ntxiv rau kev nyuaj siab yuav tsum paub txog cov tsos mob.
Cov tshuaj dab tsi Antidepressant yuav nrog cov me nyuam yaus St.
St. John lub wort muaj peev xwm los tawm tswv yim nrog ntau ntau hom kev kho mob antidepressant , xws li:
- Xaiv cov serotonin reuptake inhibitors (SSRIs) - Cov tshuaj ua hauj lwm los ntawm kev thaiv cov kab mob ntawm serotonin nyob rau hauv cov hlab ntsha hlwb, ua kom nce tus nqi ntawm serotonin preset kom khi nrog thiab sib txuas lus ib lub teeb liab, rau tom ntej ntawm tes.
- Selective norepinephrine reuptake inhibitors (SNRIs) - Cov tshuaj no nce cov tshuaj serotonin thiab norepinephrine rau hauv lub hlwb.
- Tricyclics antidepressants - Tricyclic antidepressants yog cov tshuaj qub uas tau nce cov tshuaj serotonin thiab norepinephrine hauv lub hlwb.
- Monoamine oxidase inhibitors (MAOIs) - MAOI nce serotonin, norepinephrine, thiab ntau npaum li cas nyob rau hauv lub hlwb.
Cov tshuaj uas muaj rau cov chav kawm no muaj xws li:
Xaiv xim serotonin rov qab tuaj dua:
- Prozac (fluoxetine)
- Paxil (paroxetine)
- Zoloft (sertraline)
- Celexa (citalopram)
- Luvox (fluvoxamine)
- Lexapro (escitalopram)
- Symbiax - Symbiax yog ib qho kev sib txuas ntawm Prozac (fluoxetine) thiab Zyprexa (olanzapine)
Xaiv cov kev xaiv los ntawm cov neeg tsis paub qab hau norepinephrine:
- Cymbalta (duloxetine)
- Savella (txhuas yam)
- Effexor (venlafaxine)
- Pristiq (desvenlafaxine)
Tricyclic antidepressants:
- Elavil (amitriptyline)
- Tofranil (imipramine)
- Ascendin (amoxapine)
- Anafranil (clomipramine)
- Pamelor (nortryptyline)
- Norpramin (desipramine)
- Vivactil (protryptyline)
- Surmontil (trimipramine)
- Sinequan (doxepin)
Monoamine oxidase inhibitors:
- Parnate (tranycypromine)
- Nardil (phenelzine)
Serotonin Syndrome
Thaum serotonin ntau ntau yog tsa ceg siab, ib qho tsis zoo thiab qee zaum muaj tus mob hu ua serotonin syndrome no tshwm sim. Cov kab mob serotonin ntau ntau kuj yog los ntawm:
- Noj siab dhau ib koob ntawm ib qho tshuaj tua kab mob
- Ua ob qho ntxiv ntau dua antidepressants los yog antidepressant ntxiv rau St. John lub wort
- Noj St. John wort los yog antidepressant ntxiv rau lwm hom tshuaj uas cuam tshuam thiab txhim kho serotonin theem (qhov no suav nrog qee yam tshuaj muaj nyob hauv cov khaub thuas thiab hnoos ua noj ua ke thiab muaj npe hauv qab)
Serotonin syndrome tuaj yeem ua mob hnyav, thiab muaj peev xwm ua kom tuag taus yog tias tsis kho sai. Yog tias koj siv cov tshuaj tua kab mob antidepressants nrog peb tsis muaj ib qho ntawm cov tsos mob ntawm no, hu rau koj tus kws kho mob sai li sai tau.
Cov tsos mob ntawm tus kab mob serotonin syndrome muaj xws li:
- Tsis meej pem
- Hypomania
- Kev xav
- Mob taub hau
- Coma
- Tug tsho
- Hlais
- Ua npaws
- Siab ntshav siab
- Lub plawv dhia ceev ceev
- Tsis zoo siab lub plawv dhia
- Mob plab
- Zawv plab
- Tsis thab plaub
- Nqaij rigidity
- Tsaus muag
- Overactive reflexes
- Tremor
- Tsis nco qab
Serotonin Syndrome Treatment
Thawj kauj ruam hauv kev kho mob serotonin syndrome yog nres tag nrho cov tshuaj thiab noj haus tshuaj (xws li St.
John lub wort) uas ua rau nws, tsawg kawg txog thaum cov tsos mob tau daws. Qhov no yuav tsum ua tas nrog kev pab los ntawm ib tug kws kho mob ua lwm yam teeb meem, SSRI discontinuation syndrome , muaj feem xyuam nrog txoj kev poob qis. Tsis tas li ntawd, thaum lub sij hawm SSRI discontinuation syndrome no feem ntau zoo, serotonin syndrome tuaj yeem mob loj dua.
Kev kho mob kho mob muaj xws li kev tswj hwm ntawm serotonin antagonists xws li methysergide thiab cyproheptadine. Benzodiazepines , xws li Ativan los yog Valium yuav raug muab coj los txo kom txhob muaj cov nqaij ntshiv.
Qee zaum, nws yuav tsim nyog rau qhov chaw tso pa tawm (muab ib tus neeg nyob hauv lub tshuab ua pa) los pab rau kev ua pa kom txog thaum pom cov tsos mob. Feem ntau, nws yuav siv sij hawm li 24 teev rau cov tsos mob kom qis qis, tab sis nws yuav siv ntev li ntev li 96 teev.
Tivthaiv Serotonin Syndrome
Yuav kom tsis txhob muaj tus kab mob serotonin syndrome, nws yog qhov zoo tshaj kom ua raws li koj tus kws kho mob cov lus qhia txog kev noj tshuaj koj cov tshuaj. Ntxiv mus, xyuas kom tag nrho koj cov kws kho mob paub txog lwm cov tshuaj uas koj tab tom noj, nrog rau cov tshuaj ua kom rov zoo li Stew John Wort, thiab cov tshuaj yuav tom khw (tshwj xeeb yog cov tshuaj mob khaub thuas thiab hnoos. )
Thaum kawg, koj yuav tsum tau nrhiav koj tus kws kho mob cov lus qhia txog kev hloov ntawm ib qho kev tiv thaiv antidepressant mus rau lwm tus los yog ntawm cov tshuaj antidepressant rau cov tshuaj los yog tshuaj uas yuav muaj feem xyuam rau serotonin. Tej zaum koj cov ntshav serotonin yuav ua kom zoo rau lub sijhawm tom qab koj tsis noj koj cov tshuaj noj lawm ces nws yuav tsum tau tso cai rau lub sijhawm ua ntej yuav pib siv tshuaj, tshuaj ntsuab los yog ntxiv uas yuav muaj teebmeem rau serotonin.
Lwm Cov Yeeb Tshuaj Siv Uas Yuav Ua Rau Serotonin Syndrome
Yog tias koj noj St. John lub wort los yog antidepressant nws tseem ceeb heev kom paub txog lwm cov tshuaj thiab ua rau tuaj yeem ua rau serotonin syndrome. Qee qhov no suav nrog:
- 5-HT los yog 5-HPT, 5-HT los yog 5-hydroxytryptophan yog ib qho kev noj haus ntxiv thiab yog ib qho ntawm cov precursors nyob rau hauv tsim ntawm serotonin
- Panax ginseng
- Lithium
- Selegiline
- Buspar (buspirone)
- Dextramethorphan (pom nyob rau hauv ntau hnoos thiab txias kev kho mob)
- Chlorpheniramine
- Triptans (cov mob migraine)
- Cov tshuaj mob xws li cov yas, fentanyl, meperidine, thiab tramadol
- Dopamine agonists nrog rau levodopa, amantadine, thiab bromocriptine
- Cov tshuaj tsis raws kev cai xws li yeeb dawb, LSD, ecstasy, thiab amphetamines
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov kev sib tshuam uas sau tau yog cov uas yuav tshwm sim tau rau hauv serotonin syndrome. St. John lub wort kuj tuaj yeem cuam tshuam nrog lwm cov kev siv tshuaj, xws li txo cov kev siv yeeb siv tshuaj uas yog siv los ntawm kev tsis haum rau kev hloov tsis ua rau lwm tus neeg.
Lo Lus Ceebtoom rau Kev Siv Tshuaj Noj
Kev ywj pheej ntawm St John's wort nrog qee cov tshuaj noj antidepressant tsuas yog ib qho piv txwv txog kev noj zaub mov zoo li cas - txawm tias lawv tau muag raws li ntuj tsim thiab nroj tsuag los yog txawm tias yuav organic - tuaj yeem ua rau muaj mob thiab cuam tshuam nrog lwm cov tshuaj siv zoo li cov tshuaj noj.
Ua ntej yuav siv cov tshuaj ntsuab los yog cov khoom noj haus ntxiv, nco ntsoov nyeem cov lus qhia txog kev noj haus ntxiv ua ntej kom koj tuaj yeem muaj kev txawj ntse thiab muaj peev xwm ua kom muaj kev xaiv zoo rau koj kev noj qab haus huv.
Cov kab hauv qab ntawm kev sib cuam tshuam ntawm St. John lub Wort thiab Antidepressants
Nws yog qhov tseeb hais tias kev noj haus ntxiv ntawm St John lub wort yuav nrog cov tshuaj antidepressant. Nws yuav muaj tswv yim, feem ntau, kom tsis txhob muaj kev sib koom ua ke, tiam sis nws tseem ceeb sib txawv kom nug tias yog vim li cas koj thiaj xav noj cov tshuaj no tib lub sijhawm.
Siv ob qho ua ke, tej zaum nws yuav ua hauj lwm los ua kom koj koob tsawg tshaj plaws hauv St. John's wort los yog koj tus mob antidepressant?
Qee cov neeg txiav txim siab coj St. John lub tsho sov ua ib txoj kev los txo qis los yog txo kom lawv xav tau kev noj tshuaj, thiab nws yog to taub. Nws yog ib qho tseem ceeb kom paub, txawm li ntawd los, tias St. John lub tsho yog ib qho tshuaj noj, thiab yuav tsum tau ntsia tib txoj kev uas koj yuav saib lwm yam tshuaj.
Yog tias koj tab tom nrhiav kev kho mob uas tsis yog siv tshuaj los tswj koj txoj kev nyuaj siab los sis kev txhawj xeeb, muaj ntau txoj kev xaiv. Kev kho hlwb kuj yuav pab tau tib leeg kheej, los yog nrog rau St. John's wort los yog antidepressant (los yog nrog 5-HT, lwm qhov tshuaj ntsuab ntxiv uas qee cov neeg siv kev nyuaj siab thiab ntxhov siab). Rau cov neeg uas tab tom nrhiav kev xaiv ib ntus , kev sib koom tes ntawm kev nyuab siab rau kev nyuab siab yuav yog ib qho kev xaiv tau zoo. Lwm yam kev kho mob, xws li kev coj tus cwj pwm kev coj tus cwj pwm , kev kho tus cwj pwm , thiab kev kho tus cwj pwm zoo , muaj txhua tus pom los pab ntau tus neeg tiv kev nyuaj siab.
Cov tswv yim pab yus tus kheej xws li cov phau ntawv pab yus tus kheej rau cov kev ntxhov siab lossis kev nyuaj siab pab pawg , kom cov zej zog hauv online yug yuav tsum tsis txhob poob siab thiab yuav pab tau rau ntau tus neeg.
Xyuas cov lus qhia saum toj no rau kev noj qab haus huv , uas muaj txhua yam los ntawm cov tswv yim ntawm cov khoom noj uas yuav pab tau kev nyuaj siab, rau txoj hauv kev los tuav koj cov kev xav tsis zoo thiab kawm kom zam rau koj tus kheej thiab lwm tus.
Qhov chaw:
Izzo, A., Hoon-Kim, S., Radhakrishnan, R., thiab E. Williamson. Ib qho tseemceeb rau kev sojntsuam txog kev soj ntsuam cov kev mob tshwm sim, Cov xwm txheej raug mob thiab kev sib hloov tshuaj ntawm Tshuaj Herbal. Phytotherapy Research . 2016. 30 (5): 691-700.
Khalid, Z., Osuagwu, F., Shah, B., Roy, N., Dillon, J., thiab R. Bradley. Celery Root Extract ua Inducer ntawm Mania Induction nyob rau hauv ib tug neeg mob on Venlafaxine thiab St John lub Wort. Kev Kawm Tshuaj Tiv Thaiv . 2016. 128 (7): 682-3.
National Center rau Complementary thiab Integrative Health. St. John lub Wort thiab Kev Nyuaj Siab: Hauv qhov tob. Kho dua 09/13. https://nccih.nih.gov/health/stjohnswort/sjw-and-depression.htm