ADHD Cov Neeg Laus ntawm Cov Muaj Feem Xyuam Phem Siab rau Alcoholism
Puas yog qhov tseeb tias ib nrab ntawm cov neeg laus uas qhia cov tsos mob ntawm cov tawv nqaij tsis haum hlwb (ADHD) kuj qhia txog kev puas tshuaj muaj yees, nrog rau kev quav dej quav cawv?
Puas muaj ib qho mob loj tuaj rau lwm tus? Los yog puas muaj qee cov caj txuas ntawm kev tsis sib haum xeeb, lub zog hyperactivity, impulsiveness, thiab alcoholism ? Los yog nws ib txhia ua ke ntawm ob?
Qee cov neeg tshawb nrhiav ntseeg hais tias lawv tau pom ib qho phenotype lossis "profile" ntawm cov tib neeg uas muaj ADHD nrog thiab haus cawv.
Txawm hais tias cov kev tshawb fawb ua ntej pom tias muaj kev sib txawv ntawm ADHD thiab alcoholism, kawm University of Regensburg tsis pom muaj qhov tseem ceeb ntawm ob tus neeg sib tw noob, qhov kev txhawb nqa polymorphism ntawm serotonin transporter gene (5-HTT) thiab 5-HT2c reseptor Cys23Ser polymorphism.
ADHD Cov Kev Mob thiab Cov Cwj Pwm Cawv
"Peb cov qhab-nees qhia tau tias cov tib neeg uas muaj cov tsos mob ntawm ADHD nyob rau hauv cov neeg laus yuav zoo li muaj kev pheej hmoo siab ntawm kev tsim muaj kev quav dej caw siv ," Monika Johann, kws kho mob thiab kws tshawb fawb hauv University of Regensburg thiab thawj tus kws sau ntawv. "Ntxiv mus, muaj pov thawj rau ib qho kev mob hnyav siab ntawm kev haus cawv nyob hauv cov ntsiab lus nrog ADHD."
Cov kws tshawb nrhiav tau tshawb xyuas 314 tus neeg laus quav dej quav cawv (262 tus txiv neej, 52 tus pojniam) thiab 220 tsis sib thooj ntawm kev tswj kev noj qab haus huv, tag nrho cov tsiaj ntawv German.
Txhua tus neeg tau raug soj ntsuam rau cov kev puas siab puas ntsws, xws li kev siv tshuaj yeeb dej caw (nrog rau kev quav dej caw), ADHD, thiab kev tsis sib haum xeeb ntawm tus kheej (APD).
Cov chaw ntawm Genetic Liability
Cov neeg mob uas muaj keeb kwm ntawm kev puas siab puas ntsws, xws li kev nyuaj siab thiab tus mob schizophrenia , thiab cov uas muaj kev quav yeeb quav tshuaj yeeb dej cawv thiab nicotine raug tshem tawm ntawm kev tshawb xyuas.
Genotyping tau ua tsis paub txog kev tshawb nrhiav pom, nrog kev tsom mus rau 5-HTT tus neeg txhawb nqa thiab 5-HT2c Cys23Ser polymorphism.
"Ua ntej neuroendocrine kev sib tw nrog cov tshuaj hu ua fenfluramine nrog cov tshuaj ADHD los yog alcoholism qhia zoo sib txawv hauv serotonergic neurotransmission thaum piv rau tej yam kev kawm," explained Johann. "Cov lus teb tshwm sim rau fenfluramine yog ib qho kev nce ntxiv hauv qhov kab mob circulating prolactin.Yog li ib txwm nce ntxiv nrog cov ADHD los yog haus cawv los ntawm cov kabmob loj uas tsim los ntawm cov hluavtaws los ntawm cov tshuaj phenfluramine prolactin yog 5-HTT thiab 5-HT2c receptors Yog li, ob leeg plausible li qhov overlapping qhov chaw ntawm genetic lav ADHD thiab alcoholism. "
Genetic Predisposition tsis pom
Tsis yog lawv tus kheej, li cas los xij, qhov tshwm sim muaj feem cuam tshuam hauv cov qauv kuaj ntawd. "Peb cov ntaub ntawv qhia tias 5-HTT tus neeg txhawb nqa thiab 5-HT2c Cys23Ser polymorphism tsis tuaj yeem ua rau tus kabmob genetic predisposition rau ADHD thiab haus cawv," said Johann. "Txawm li cas los, ob peb lwm tus neeg sib tw kis tau tsis tau tshawb xyuas."
Txawm li cas los xij, cov kev tshawb nrhiav pom muaj phenotype txawv, ib txoj hauv kev los mus soj ntsuam ib qho kev zoo los yog coj cwj pwm.
Kev tshawb xyuas Regensburg tau pom tias cov neeg laus muaj dej cawv nrog ADHD tau haus ntau dua txhua hnub haus dej cawv txhua lub hli, muaj hnub nyoog pib ntawm kev haus cawv , ntau dua kev xav txog kev tua tus kheej, ntau dua ntawm kev hais plaub, APD.
Yog li, txawm hais tias tsis muaj kev txhawb nqa rau ib qho kev tshuaj ntsuam genetic predisposition, "cov ntaub ntawv qhia tias ib zaug dua tias ADHD txhais tau tias yuav muaj kev pheej hmoo siab rau kev tsim cawv kev vam meej," said Ema Loncarek, kws kho mob, thiab kws kho mob hauv chaw kho mob hlwb University of Regensburg. Loncarek ua haujlwm nyob rau hauv pawg ntseeg rau kev quav tshuaj yeeb txhaum cai, muab kev kho mob thiab kev kho mob.
ADHD Addicts Nyuaj rau Kov
"Dr. Johann cov kev tshawb pom ntawm lub phenotype zoo heev uas peb pom nyob rau hauv cov tshuaj quav yeeb quav tshuaj yeeb nrog ADHD, thiab tau piav dab tsi los ntawm lwm tus neeg sau ntawv Peb pom tias niaj hnub siv tshuaj yeeb nrog ADHD nyuaj. kev siv yeeb tshuaj ua ntej tshaj lwm tus neeg, hloov ntxov ua ntej 'tshuaj nyuab', noj ntev dua mus kho, thiab siv sijhawm ntev los kho cov kev kho mob kom tiav. "
Txoj kev tshawb pom pom hais tias hauv cov pab pawg ntawm alcoholics, cov ntsiab lus nrog ADHD hauv neeg laus yog:
- Tsib dua 10 zaug ntau dua li cov pejxeem
- Plaub lub xyoo yau ntawm qhov pib ntawm kev quav dej quav cawv
- Drank 50 grams ntau dua haus cawv txhua hnub
- Ob zaug li yuav muaj tsev neeg keeb kwm ntawm kev quav dej caw
- Peb lub sij hawm ntau dua ntawm tus kab mob kev tsis sib haum xeeb
- Xya lub sij hawm ntau dua yuav tau ntsib kev hais plaub ntug
- Ntau tshaj ob zaug cov zaus ntawm kev xav suicidal
Kev Kho Mob Tshwj Xeeb
Ob leeg Johann thiab Loncarek tau hais txog kev tsim kho thiab kev soj ntsuam ntawm cov kev khomob tshwjxeeb uas hais txog "phenotypical specifics" thiab cov kabmob uas muaj kabmob xws li alcoholism thiab ADHD. Thaum cov tshuaj kho mob, lawv tau pom, tau ntsuam xyuas ntau tshaj rau cov kev kho mob ntawm ADHD thaum yau, tsis pom zoo rau cov neeg uas ua txhaum ADHD rau cov neeg laus. "
"ADHD zoo li tsis tshua muaj nqi rau cov neeg laus," said Johann, "tsis tau zoo li yuav yog qhov tseem ceeb tshaj plaws rau kev haus cawv."
Source:
Johann M, li al. Comorbidity ntawm Cawv Kev Ntseeg Nrog Kev Tiv Thaiv Tsis Muaj Mob Siab Tsis Taus: Qhov txawv ntawm Phenotype Muaj Kev Tshaj Tawm Txog Phev Plaub Ntug, tab sis Tsis Nyob Genotype (Serotonin Transporter thiab 5-Hydroxytryptamine-2c Receptor). Alcoholism: Soj ntsuam & Kev tshawb nrhiav kev tshawb nrhiav . 2003.