Qeb hoob kawm ntawm yeeb tshuaj tseem siv los kho atypical kev nyuaj siab
Monoamine oxidase inhibitors (MAOIs) yog thawj hom tshuaj tiv thaiv antidepressant tsim thaum ntxov xyoo 1950. Thaum lawv tau raug ntau los ntawm lwm cov chav kawm ntawm cov tshuaj, MAOIs tseem muaj lawv qhov chaw nyob rau hauv kev kho mob, feem ntau tsim nyog rau cov neeg mob hauv atvical kev nyuaj siab .
Yuav ua li cas MAOIs Ua Haujlwm
Txoj kev xav yog kev tswj hwm los ntawm cov tshuaj hauv lub hlwb hu ua neurotransmitters .
Muaj peb hom neurotransmitter feem ntau muab kev koom tes hauv kev xav- serotonin , norepinephrine , thiab dopamine -xoo uas yog cais raws li monoamines (txhais tau tias lawv muaj ib leeg amino acid ).
Siv cov neurotransmitters feem ntau raug rhuav tshem los ntawm ib qho enzyme hu ua monoamine oxidase. Txawm li cas los xij, yog hais tias tus txheej txheem muaj zog heev thiab ntau cov neurotransmitters puas lawm, tus neeg muaj peev xwm tsim muaj cov tsos mob ntawm kev nyuab siab nyob rau hauv daim ntawv ntawm kev nyuaj siab.
MAOIs ua haujlwm los ntawm kev thaiv qhov kev ua si ntawm no enzyme, uas ua rau ntau dua ntawm cov neurotransmitters thiab kev txhim kho hauv cov tsos mob siab.
Cov tshuaj tua kab mob MAOI tau pom zoo siv rau hauv Tebchaws Asmeskas muaj xws li:
- Marplan (isocarboxazid)
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- Emsam - selegiline transdermal
Thaum lub sij hawm MAOIs tsis nquag siv rau thawj kev kho mob kev nyuab siab, lawv yog qhov zoo tshaj plaws rau cov neeg muaj kev nyuaj siab hauv atypical . Qhov no yog ib qho kev nyuab siab ntawm kev nyuab siab heev, kev pw tsaug zog ntau, kev tsis txaus siab heev, thiab kev tsis ua haujlwm ntawm tus kabmob (mob qis dua vim pom tias muaj qhov hnyav ntawm ob txhais ceg thiab caj npab).
MAOIs feem ntau yog siv los kho tus kab mob Parkinson's disease thiab kuj siv tau ua lwm yam kev kho mob (tiv thaiv) kev kho mob loj heev.
Vim li cas MAOIs Muaj Feem Ntau Siv
Niaj hnub no, kev nyuaj siab feem ntau kho yog nrog lwm chav tshuaj uas hu ua serotonin reuptake inhibitors (SSRIs) uas muaj Zoloft (sertraline) thiab Paxil (paroxetine) .
Qhov no yog vim, ib feem, rau ntau cov kev phiv thiab tshuaj sib raug zoo los ntawm cov tib neeg hauv MAOIs.
Ib qho ntawm cov kev txhawj xeeb loj yog cov kev txwv kev noj haus uas cov neeg nyob hauv MAOI yuav tsum tsis txhob noj cov khoom noj thiab dej haus uas muaj tyramine . Cov no muaj xws li daim siab thiab cov khoom noj khoom haus xws li cheese thiab dej cawv. Vim tias tyramine cuam tshuam txog ntshav siab thiab MAOI nce tyramine, ntxiv rau cov khoom noj yuav ua rau muaj kev kub ntxhov thiab tejzaum nws tuag.
Cov tshuaj MAOIs kuj yog txuam nrog cov tsos mob tawm yog tias kev kho mob puas tau nres. Thaum lwm tus antidepressants kuj muaj cov kev mob tshwm sim no, nws xav tau tshwj xeeb tshaj yog nrog MAOIs. Yog li ntawd, cov tshuaj yuav tsum tau muab tshuaj tua kab mob los ntawm kev saib xyuas ntawm tus kws kho mob thiab nrog kev sib kis ntawm qhov chaw nyob ob los ntawm tsib lub limtiam ua ntej yuav pib siv tshuaj tiv thaiv tshiab antidepressant.
Tshuaj Kev Sib Thoob
Ib qho teeb meem loj ntawm MAOIs yog ntau yam kev siv tshuaj yeeb dej caw tus neeg muaj peev xwm paub txog thaum kho. Cov no suav nrog cov tshuaj noj thiab cov tshuaj yuav tom khw thiab cov tshuaj noj. Yog tias tsis muaj kev tswj hwm, ib qho MAOI cuam tshuam nrog lwm cov kev kho los yog txo cov hauj lwm zoo ntawm MAOI nws tus kheej.
Daim ntawv teev cov tshuaj yeeb dej caw muaj xws li:
- Amphetamines
- Antihistamines
- Tshuaj tua kab mob
- Hawb pob tshuaj
- Cov tshuaj ntshav siab
- BuSpar (buspirone)
- Cocaine
- Demerol (pethidine)
- Prozac (fluoxetine)
- Ritalin (methylphenidate)
- Tegretol (carbamazepine)
- Tricyclic antidepressants
- Tryptophan
- Wellbutrin (bupropion)
Nws yog, qhov tseeb, xam tias muaj kev phom sij yog tias ib qho MAOI raug coj los siv nrog yeeb yaj kiab, Demerol, Prozac, lossis cov tshuaj tiv thaiv kev mob siab ntsws (tricyclic antidepressant). Feem ntau hais lus, MAOIs yuav tsum tsis txhob siv nrog lwm hom antidepressant, suav nrog lwm tus MAOI.
Lo Lus Ntawm
MAOIs, thaum tsis tshua siv niaj hnub siv dua SSRIs, tuaj yeem siv tau rau cov neeg mob nyuab heev.
Yog tias kws kho mob MAOI, nws tseem ceeb heev uas koj yuav tsum qhia koj tus kws kho mob txog txhua yam thiab txhua yam tshuaj koj noj, kev cai lossis lwm yam. Tshaj li, thaum pib kho, koj yuav tsum tsis txhob noj tshuaj, nrog rau cov tshuaj tua kab mob khaub thuas thiab dej dawb, tsis tas nrog koj tus kws kho mob tham.
> Source:
> Grady, M. thiab Stahl, S. "Cov tswv yim coj los piav txog MAOIs: kev sib cav sib ceg thiab rhuav tshem teeb meem." CNS Spectrums 2012; 17: 2-10. DOI: 10.1017 / S109285291200003X.