Cov tshuaj kws kho mob tau paub los ua ke nrog lwm cov tshuaj thiab qee yam khoom noj, tab sis lawv tuaj yeem cuam tshuam los ntawm kev haus luam yeeb-thiab kev txiav luam yeeb.
Yuav Siv Li Cov Tshuaj Yuam Txuam Tshuaj Los ntawm Kev Haus Luam Yeeb
Cov khoom noj uas peb noj yog tawg (metabolized) ua cov as-ham uas peb lub cev siv tau. Txoj kev no pib nrog enzymes, uas ua raws li catalysts rau cov txheej txheem kev zom.
Muaj ntau hom kev enzymes. Ib txhia ntawm lawv pab tawg paj hlwb, qee cov hauj lwm ntawm carbohydrates, thiab lwm tus neeg ntawm cov rog.
Qhov zoo sib xws, muaj ntau lub cev uas muaj metabolised cov tshuaj. Ib qho ntawm cov enzymes, CYP1A2, yog cuam tshuam los ntawm qee yam tshuaj hauv cov pa luam yeeb. Cov co toxins no, hu ua PAHs (hydrocarbons polycyclic) muaj peev xwm paub tias muaj qee lub peev xwm carcinogens hauv cov pa luam yeeb .
Thaum PAH tau los sib cuag nrog CYP1A2 lub enzyme ua ntau dua. Qhov no ua rau cov tshuaj uas tau tawg los ntawm CYP1A2 kom metabolized ntau dua li qhov lawv yuav tsum tau. Yog li ntawd, cov neeg haus luam yeeb feem ntau xav tau ntau dua qhov uas yuav tsum tau txhaj.
Thaum kev haus luam yeeb nres sai, xws li mus rau hauv lub tsev kho mob uas tsis pub haus luam yeeb los yog tshem tawm cov qaib ntxhw, CYP1A2 kev ua si qeeb thiab cov koob tshuaj loj tuaj yeem ua rau ntau dhau lawm. Lub sij hawm uas tsis zoo los ntawm kev siv tshuaj kho mob kuj nce thiab.
Nws yog ib qho tseem ceeb uas yuav tsum tau muab tshuaj kho thiab tau kho los ntawm tus kws kho mob thaum tus neeg tawm kev haus luam yeeb.
Cov Tshuaj Cov Tshuaj Uas Siv Tau Cov Metabolized los ntawm CYP1A2
Raws li koj tau pom los ntawm daim ntawv teev npe no, ntau cov tshuaj siv metabolized los ntawm CYP1A2. Qee leej yuav tsis ua rau muaj kev phiv tshuaj tom qab haus luam yeeb tawm, tab sis lwm tus tuaj yeem cuam tshuam loj heev yog tias cov koob tshuaj tsis hloov lossis kho thaum ib tus neeg haus luam yeeb.
Tsis txhob ua siab deb qhia koj txoj kev haus luam yeeb nrog koj pawg neeg kho mob kom lawv muaj peev xwm ua qhov muag ntawm cov kev hloov koj tuaj yeem ntsib.
- Alosetron (Lotronex): Antidiarrheal siv los kho cov tsos mob irritable syndrome
- Clozapine: kev siv yeeb siv tshuaj los kho tus mob schizophrenia
- Flutamide (Eulexin): tshuaj hormone-based kws khomob
- Fluvoxamine (Luvox): siv los kho tus cwj pwm phem lossis kev coj cwj pwm
- Frovatriptan (Frova): siv los kho migraine mob taub hau
- Haloperidol (Haldol): kho cov mob schizophrenia, mob hlwb, thiab siv rau tics thiab suab lus hais ntawm Tourette's syndrome
- Imipramine (Tofranil): siv los kho kev nyuaj siab
- Melatonin: dhau ntawm lub txee ntxiv siv rau kev pw tsaug zog
- Mexiletine (Mexitil): kev siv tshuaj tua kab mob los kho cov plawv dhia tsis haum
- Mirtazapine (Remeron): antidepressant siv los kho kev nyuaj siab.
- Olanzapine (Zyprexa): siv rau tus mob schizophrenia, kev puas siab puas ntsws bipolar
- Propanolol (Inderal): siv los kho tshuaj tiv thaiv, angina (hauv siab mob), ntshav siab, plawv dhia plawv, thiab lwm yam plawv los sis lub plawv. Kuj tseem siv los kho migraine taub
- Ramelteon (Rozerem): sedative siv rau insomnia
- Rasagiline (Azilect): MAOI thiab antidepressant uas siv tau los kho tus kab mob Parkinson's disease
- Ropinirole (Yuav Tau Ua): dopamine promoter uas yuav siv los kho tus kab mob Parkinson thiab tsis muaj ciaj ceg
- Tacrine (Cognex): siv los kho Alzheimer's disease
- Theophylline: cov tshuaj tiv thaiv mob hawb mus ntev
- Tizanidine (Zanaflex): cov leeg mob ntsaws los siv kho cov nqaij ntshiv
- Triamterene (Dyrenium): Cov tshuaj tsw qab uas siv dej kua thiab ntshav siab
- Zolmitriptan (Zomig): triptan siv los kho migraine mob taub hau
Caffeine Tseem Muaj Metabolized los ntawm CYP1A2
Feem ntau cov neeg tsis haus luam yeeb yuav qhia rau koj tias kas fes tau muaj cov nyhuv rau lawv tom qab txiav luam yeeb lawm. Lub khob niaj zaus los yog ob hnub thaum sawv ntxov tawm hauv lawv sab nraud thiab tshee.
Lawv yuav chalk nws mus rau cov tsis muaj nicotine , thiab uas ua si lub luag hauj lwm, tab sis nws yuav tau ntau dua ua nrog CYP1A2.
Cov neeg haus luam yeeb metabolize caffeine nyob kwv yees li ntawm plaub zaug tus nqi ntawm cov neeg haus luam yeeb. Nws tsis yog xav tias haus cov dej kas fes qis los yog lwm cov dej haus caffeinated yog tsis nco dheev tom qab haus luam yeeb tso tawm. Yog tias koj nyuam qhuav txiav, koj yuav sim txiav koj cov kev noj haus hauv ib nrab ntawm cov caffeine thiab pom tias koj xav li cas. Koj tuaj yeem txo los yog nce raws li qhov ntawd.
Nicotine thiab Tshuaj Kho Mob
Nicotine hauv luam yeeb thiab kev hloov tshuaj nicotine kuj tseem tuaj yeem cuam tshuam li cas lub cev muaj peev xwm teb tau rau qee cov tshuaj.
Nicotine constricts cov hlab ntsha thiab tej zaum yuav npog qhov nqus dej ntawm cov tshuaj insulin.
Nicotine yog ib qho stimulant uas ua rau lub plawv dhia thiab ntshav siab. Nws tuaj yeem ua rau kom txo cov kev kho mob uas siv los kho tib yam nkaus. Nws kuj yog txuam nrog kev txo kom loog los ntawm benzodiazepines (tranquilizers) thiab qhov mob tsawg dua los ntawm qee cov tshuaj opioids.
Teem Sij Hawm Nrog Koj Tus Kws Kho Mob
Yog tias koj noj cov tshuaj kws kho mob tau noj thiab haus luam yeeb (lossis koj npaj), nrog koj tus kws kho mob txheeb xyuas seb lawv yuav raug cuam tshuam los ntawm kev haus luam yeeb tawm.
Txoj xov zoo yog qhov kev txiav luam yeeb yuav ua kom koj lub cev muaj mob thiab kev loj hlob. Koj tuaj yeem pom tias qee cov tshuaj tau muab tshem tawm thaum koj lub cev rov qab los ntawm kev quav tshuaj nicotine .
Yog koj npaj txav txiav, siv cov kev pabcuam txiav luam yeeb ua lub sijhawm pib. Yog tsis muaj lub sij hawm zoo li lub sijhawm tam sim no pib ua hauj lwm ntawm kev ua koj npau suav kev muaj tiag.
Qhov chaw:
Australian Prescriber. Haus Luam Yeeb thiab Tshuaj Kev Sib Txuam. https://www.nps.org.au/australian-prescriber/articles/smoking-and-drug-interactions.
Cov Tshuaj Phom sij. Tau Paub Txog Enzyme: CYP1A2. http://www.pharmacytimes.com/publications/issue/2007/2007-11/2007-11-8279.