Cov noob caj noob ces ntawm kev puas siab puas ntsws Bipolar
Yog tias koj muaj kev puas siab puas ntsws bipolar thiab koj xav tias muaj me nyuam, ib qho ntawm cov lus nug koj muaj peev xwm nug koj tus kheej yog tias koj yuav kis tau koj cov kev puas siab puas ntsws bipolar rau tus me nyuam. Puas muaj kev puas siab puas ntsws bipolar? Lub hauv paus ntawm genetics hauv kev puas siab puas ntsws bipolar yog dab tsi?
Puas muaj kev puas siab puas ntsws Bipolar?
Peb tau paub txog qee lub sij hawm uas muaj kev puas siab puas siab ntsws bibles hauv tsev neeg, thiab tam sim no, nrog cov kabmob genomic, peb tabtom kawm txog lub luag haujlwm ntawm caj ces caj dab.
Thaum lub luag hauj lwm ntawm heredity yog tseeb ntawm tsev neeg thiab ob leeg kev tshawb fawb, yuav tsum tshawb nrhiav ntxiv.
Qhov kev pheej hmoo siab ploj tag nrho ntawm kev tsim kev puas siab puas ntsws bipolar yog xav tau qhov chaw nruab nrab ntawm 1 thiab 4 feem pua, nyob ntawm qhov txhais, nrog rau qhov nruab nrab hnub nyoog ntawm kev kuaj mob yog 18.
Cia peb saib txog yam uas peb paub txog tsev neeg keeb kwm thiab kev puas siab puas ntsws, thiab tom qab ntawd cov kws kho mob caj dab tau pom txog lub luag haujlwm ntawm cov noob caj noob ces hauv kev puas siab puas ntsws bipolar thiab lwm yam kev mob hlwb.
Tsev Neeg Keeb Kwm ntawm Kev Puas Siab Puas Ntsws Bipolar
Kev puas siab puas ntsws bipolar yog qhov feem ntau pom tias yog ib qho tseem ceeb tshaj plaws ntawm kev puas siab puas ntsws mob hlwb raws li kev rov xyuas cov kab kos keeb kwm tsev neeg. Piv txwv li, ntawm no yog cov ntaub ntawv los ntawm txoj kev tshawb fawb uas pom muaj kev sib raug zoo nrog tsev neeg nrog kev puas siab puas ntsws bipolar:
- Ib tug me nyuam ntawm ib tus niam txiv uas muaj kev puas siab puas ntsws bipolar thiab ib qho tsis muaj li 15 txog 30 feem pua ntawm kev muaj BP.
- Yog tias ob leeg niam txiv muaj kev puas siab puas ntsws bipolar, nws muaj 50 feem pua ntawm 75 feem pua ntawm cov me nyuam ntawm lawv tus kheej, thiab.
- Yog tias koj twb muaj ib tus menyuam nrog BP lawm, nws muaj li 15 txog 25 feem pua uas muaj lwm tus menyuam tuaj yeem muaj.
- Yog tias ib tus ntxaib muaj BP, nws muaj li ntawm 85 feem pua uas muaj lwm tus yuav zoo li ntawd. Hauv peb lwm cov kev tshawb fawb, lub sij hawm ntawm tus ntxaib tib yam kuj muaj kev puas siab puas ntsws bipolar yog txij li 38 mus rau 43 feem pua nrog cov poj niam uas tsis sib thooj (sib tw) uas yog nruab nrab ntawm 4.5 thiab 5.6 feem pua.
Lwm cov kev tshawb fawb tau pom tias kev puas siab puas ntsws bipolar hauv tsev neeg, tab sis tsis yog tag nrho rau qib kawm no. Qee yam ntawm kev puas siab puas ntsws bipolar kuj tshwm sim nyob rau hauv tsev neeg xws li cov kabmob ntawm kev mob nkeeg ( mob lub siab (depression), ntau zaus ntawm lub sijhawm, muaj kev puas siab ntsws , kev tua tus kheej, kev siv ceev ceev, kev haus dej cawv, kev phom sij, thiab kev ua haujlwm (lossis tsis muaj) rau cov tshuaj xws li lithium thiab lwm yam tshuaj.
Cov hnub nyoog ntawm pib ntawm kev puas siab puas ntsws bipolar feem ntau yau rau cov me nyuam uas muaj niam txiv los yog niam tais yawm txiv nrog nrog ntau dua kev puas siab puas ntsws bipolar.
Genetics vs Ib puag ncig thiab Bipolar tsis meej (Qhov xwm vs Nurture Controversy)
Thaum muaj kev puas siab puas ntsws bipolar hauv tsev neeg nws thov tau cov lus nug: Qhov kev pheej hmoo loj heev muaj feem xyuam nrog noob caj noob ces (kev ua ob peb ua ke) los yog qhov chaw nyob. Nws zoo nkaus li tias ob qho tib si mechanisms zaum ntawm qhov chaw ua si thiab pab txhawb qhov kev puas siab puas ntsws bipolar .
Cov noob caj noob ces ntawm kev puas siab puas ntsws Bipolar
Txawm tias nws sau rau hauv cov tsev neeg, nws nyuab dua los txheeb cov kev mob caj ces tshwj xeeb. Cov kev tshawb fawb saib ntawm noob caj noob ces ntawm kev puas siab puas ntsws muaj peev xwm nrhiav tau ib tus noob uas yog ib qho causative (piv txwv, raws li yog qhov teeb meem nrog cystic fibrosis.) Tiam sis, nws pom tias muaj ntau thaj chaw chromosomal nrog ntau lub noob (polygenic,) txhua tus ntawm uas muaj cov nyhuv me hauv kev ua kom lub cev tsis zoo.
Variants nyob rau hauv cov noob xws li ANK3, CACNA1C, NCAN, ODZ4 thiab xav tias yuav ua rau mob nyhav, tiam sis tsuas piav me ntsis feem pua ntawm cov kev pheej hmoo. Tsis tas li ntawd, feem ntau ntawm cov neeg uas muaj cov "ntawm cov kev pheej hmoo alleles" tsis muaj kev puas siab puas ntsws bipolar.
Genetics thiab Cov Lus Teb rau Cov Tshuaj Bipolar
Ib qho teeb meem cais uas tau muab sau tseg nrog peb qhov kev nkag siab tshiab ntawm noob caj noob ces yog tias cov noob caj noob ces tej zaum yuav ua lub luag haujlwm ntawm tus neeg ua teb rau cov tshuaj rau kev puas siab puas ntsws bipolar. Piv txwv li, cov neeg uas muaj ob daim qauv ntawm tus kab CYP206 yuav tsis muaj cov tshuaj metabolizers ntawm cov tshuaj xws li cov tshuaj respiratone thiab aripiprazole.
Raws li teev saum toj saud, ntau npaum li cas tus neeg teb rau cov tshuaj xws li lithium yuav khiav hauv tsev neeg.
Cov noob caj noob ces ntawm kev puas siab puas ntsws Bipolar thiab lwm cov kev puas siab puas ntsws
Hauv kev saib ntawm kev mob caj ces, nws tau raug sau tseg tias lawv yog sib sib zog nqus ntawm cov noob nqaij sib txawv nrog rau kev puas siab puas ntsws thiab tus mob schizophrenia , tus kab mob schizoaffective , thiab kev nyuaj siab .
Koj Yuav Tsum Muaj Cov Menyuam Yog Tias Koj Muaj Bipolar Disorder?
Paub tias muaj kev pheej hmoo siab ntawm kev puas siab puas ntsws bipolar rau cov me nyuam ntawm cov neeg muaj kev puas siab puas ntsws bipolar, yog cov niam txiv muaj teeb meem muaj menyuam?
Qhov no yog ib lo lus nug uas tsis muaj qhov kev txhawj xeeb lossis tsis yog. Muaj ntau txoj kev kho mob uas muaj peev xwm muaj ib feem ntawm lub cev. Tsis tas li, tsis muaj ib lub noob qes los yog ib qho zuj zus uas "guarantees" ib tug me nyuam yuav pib muaj kev puas siab puas ntsws bipolar.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias tsis muaj dab tsi hais tias muaj ib tug me nyuam uas tsim muaj kev puas siab puas ntsws tsis yog ib qho kev ua tiav zoo.
Qhov tseeb cov lus teb yog cov niam txiv yuav tsum txiav txim siab yog qhov zoo rau lawv tus kheej thiab lawv tus me nyuam yav tom ntej. Yog koj paub txog koj tsev neeg keeb kwm, txawm li cas los xij, yuav pab tau koj tus menyuam kom saib xyuas nws yog tias nws pom muaj cov cim lossis cov tsos mob kom paub txog qhov mob ua ntej qhov kev mob tshwm sim.
Cov kab hauv qab ntawm noob caj noob ces, muaj mob, thiab kev puas siab puas ntsws Bipolar
Nws pom tseeb tias muaj ib lub luag haujlwm tseem ceeb hauv kev txhim kho ntawm kev puas siab puas ntsws bipolar, tab sis lub luag hauj lwm zoo li no yog cov polygenic (tswj tau me ntsis los ntawm ntau ntau yam noob) thiab qhov nyuaj. Tsis tas li, tsis muaj ib lossis ob peb yam kev txawv ntawm lub cev uas ua rau muaj kev puas siab puas ntsws bipolar, theej, kev sib txawv ntawm cov noob uas yuav ua rau tus neeg mob nyhav los tsim muaj kev puas siab puas ntsws bipolar. Ib tsev neeg keeb kwm ntawm qhov teeb meem no tsis yog vim li cas thiaj li tso tawm los ua ib tug niam txiv. Koj tuaj yeem xav kawm txog cov xim liab rau kev puas siab puas ntsws bipolar hauv cov menyuam yaus , thiab ntau hom mob txawv .
> Qhov chaw:
> Alsabban, S., Rivera, M., thiab P. McGuffin. Genome-Wide Searches rau kev puas siab puas ntsws Bipolar Genes. Kev Tshaj Tawm Txog Kev Mob Hlwb . 2011. 13 (6): 522-7.
> Charney, A., Ruderfer, D., Stahl, E. thiab al. Evidence rau Genetic Heterogeneity ntawm Clinical Subtypes ntawm Bipolar Teeb Meem. Psychiatry Txhais Ntawv . 2017. 7 (1): e993.
> Craddock, N., thiab P. Sklar. Cov noob caj noob ces ntawm kev puas siab puas ntsws Bipolar. Lancet . 2013. 381 (9878): 1654-62.
> Goes, F. Genetics ntawm kev puas siab puas ntsws Bipolar: Hloov tshiab thiab Kev Tuaj Yav Tom Ntej. Psychiatric Clinics ntawm North America . 2016. 39 (1): 139-55.
> Kerner, B. Ua Tus Deeper To taub txog cov noob caj noob ces ntawm kev puas siab puas ntsws Bipolar. Frontiers hauv Psychiatry . 2015. 6: 105.