FDA hais txog kev ceeb toom txog kev mob nyhav tab sis muaj mob loj
Lamotal (lamotrigine) yog ib qho tshuaj yeeb yaj kiab uas feem ntau siv los ua kom tus neeg nyob nrog kev puas siab puas ntsws bipolar . Nws ua hauj lwm los ntawm moderating huab variations hauv kev xav thiab tshwj xeeb tshaj yog pab tau rau kev kho mob kev nyuab siab heev. Cov tshuaj noj tau siv ntau thoob plaws txij li qhov qhia txog xyoo 1994 thiab yog hnub no ntawm cov koom haum World Health Organization cov npe ntawm cov Tshuaj Tseem Ceeb.
Tsis tau, txawm tias nws cov txiaj ntsim tau txais txiaj ntsig, Lamictal nws cov downsides. Hauv qee leej neeg, Lamictal tau paub tias ua rau mob pob khaus thiab o tuaj, ua qhov teeb meem uas tshwm sim los ntawm US Food and Drug Administration (FDA) los muab cov lus ceeb toom dub rau cov neeg tau txais kev pab txog cov kev mob tshwm sim uas tsis tshua muaj tshwm sim, tab sis feem ntau.
Tshuaj Tiv Thaiv Lawm thiab Feem Xyuam (Hypersensitivity Reactions)
Nyob rau hauv lawv cov lus qhia, FDA tau ceeb toom txog ntau qhov kev tawm tsam kev sib haum xeeb uas tshwm sim rau cov tib neeg uas siv Lamictal. Qhov tshuaj tiv thaiv mob hypersensitive yog ib qho uas muaj mob los yog tshuaj ua rau lub cev tsis muaj zog, ua rau muaj kev tsis haum lossis qhov kev kho mob rau nws lub cev.
Nrog Lamictal, cov no tuaj yeem muaj qhov tshwm sim hu ua Stevens-Johnson syndrome (SJS), tshuaj lom epidermal necrolysis (TEN), thiab tshuaj tiv thaiv eosinophilia thiab cov tsos mob system (DRESS syndrome).
Txhua yam ntawm cov mob no ua rau mob hnyav (ib txhia hais tias "npau taws") ua pob uas tom qab ob rau yim lub lim tiam ntawm kev siv yeeb tshuaj.
Kev nyiaj hli yog qhov tseem ceeb, xws li 5 feem pua mus txog 30 feem pua.
Txhua cov tshuaj tiv thaiv yog txhais los ntawm nws cov xeeb ceem:
- Cov kab mob Stevens-Johnson Syndrome (SJS) feem ntau yuav dhau los ntawm cov tsos mob ua npaws xws li mob taub hau, kub cev, mob caj pas, hnoos, raws plab, thiab ntuav. Qhov no tuaj yeem ua raws li kev sib txig sib luag ntawm lub cev sai sai, tawm ntawm lub ntsej muag thiab tus nplaig, thiab cov hnyuv loj ntawm lub qhov ncauj ntawm lub qhov ncauj, qhov ntswg, thiab qhov muag. Cov pob liab liab tuaj yeem ua tau mob zoo heev thiab, qee zaum, ua rau tus neeg saib xyuas thiab ua kom tawv nqaij.
- Cov tshuaj tua hluavtaws epidermal necrolysis (TEN) yeej tseem zoo li SJS, tab sis zuj zus tuaj. TEN txhais tias tshem tawm ntawm ntau tshaj 30 feem pua ntawm cov tawv nqaij tsis yog tawm tsam SJS uas yog tsawg dua 10 feem pua. Tshaj li, qhov kev pheej hmoo ntawm kev tuag ntawm TEN yog nruab nrab ntawm plaub thiab tsib lub sij hawm ntau dua SJS.
- Kev hnoos hnoos hlais no yog ib qho tshuaj tiv thaiv kab mob uas tuaj yeem tsim ua pob khaus ua ke nrog lwm cov kev mob tshwm sim xws li mob hnyav mob thiab muaj mob tsawg kawg ib yam kab mob loj tshaj plaws (feem ntau yog daim siab, qog, ntsws, lub plawv, cov leeg nqaij, los yog pancreas).
Txoj kev kho yuav muaj kev cuam tshuam Lamictal tam sim ntawd thiab siv cov kev pabcuam txhawb rau kev kho mob, tiv thaiv tus kabmob, thiab xyuas kom meej tias tus neeg tseem nyob hauv cov dej. Kev puas tsuaj ntawm daim tawv nqaij yog kho kom zoo ib yam rau lub cua sov. Corticosteroids feem ntau yog siv los txo qhov mob.
Cov Cim Txheej Txheem Nrog Ua Piv Txwv
By thiab loj, cov neeg uas muaj hnub nyoog qis dua 17 feem ntau yuav muaj qhov tshwm sim rau Lamictal dua cov laus. Ntxiv mus, muaj ntau ntau yam uas tuaj yeem ua rau kom muaj kev phom sij:
- Noj ntau tshaj li cov koob tshuaj uas tau pom zoo thaum pib txoj kev kho
- Ua rau lub koob ntau dhau sai thaum pib tsis txhob maj maj
- Ua rau kev kho mob sai dua thiab pib dua thaum noj tshuaj
- Noj cov tshuaj Depakene (valproic acid) lossis Depakote (sodium valproate) ua ke nrog Lamictal
Nws yuav tsum tau qhia, txawm li cas los xij, qhov hypersensitivity tej zaum kuj tshwm sim txawm tias koj noj cov tshuaj raws li kws kho. Thaum cov caj ces tshwm sim los ua si, qhov ua rau qee zaum idiopathic (lub ntsiab lus uas peb tsuas tsis paub yog vim li cas).
Dab Tsi Vev Xa Cim Qhia Peb
Lub FDA muab cov lus ceeb toom dub rau ntawm lub siab vim tias muaj cov tshuaj tiv thaiv kab mob siab tshaj plaws nrog rau lwm cov tshuaj siv los kho cov mob hauv lub siab.
Raws li lawv cov kev tshawb fawb, muaj li peb-fold ntxiv nyob rau hauv txoj kev pheej hmoo yog tias koj coj Lamictal raws li piv rau lwm lub siab tawv.
Yog tias koj muaj hnub nyoog qis dua 16 xyoos, qhov kev pheej hmoo yuav ntxiv ob zaug. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov, txawm li cas los xij, uas tsis yog tag nrho cov kev tsis haum siab yuav xaus nrog SJS. Muab tag nrho rau hauv kev xav, muaj tiag tiag tsuas yog 0.1 feem pua ntawm cov kev tshwm sim ntawm qhov kev tshwm sim tshwm sim. Thaum kawg, nws yog qhov phem heev ntawm qhov tshuaj tiv thaiv, nrog rau lwm cov laj thawj ntawm cov tshuaj yeeb dej cawv, qhia rau FDA qhov kev txiav txim siab ntau npaum li qhov tshwm sim tawm nws tus kheej.
Cov kab hauv qab yog qhov no: Yog tias koj tau ua pob liab liab thaum noj cov tshuaj Lamictal, mus ntsib koj tus kws kho mob tam sim ntawd. Yog tias nws kis tau sai, hu rau 911 lossis mus rau chav kho mob ceev ze koj. Nws yog qhov zoo dua kom tsis txhob muaj kev phom sij dua, tiam sis tsis tshua txaus ntshai.
> Qhov chaw:
> GlaxoSmithKline. " Lamictal (lamotrigine) : Cov Ntawv Xov Xwm Tshaj Tawm" Cov Thoob Plaws Peb Tog, North Carolina; hloov tshiab Kaum Ob Hlis 2016.
> Wang, X .; Iv, B .; Wang, H .; li al. "Lamotrigine-ntxias ua rau cov tshuaj tiv thaiv tsis txhob mob siab: Hloov cov ntaub ntawv txij xyoo 1999-2014." Phau Tshuaj Hlwb ntawm Neuroscience. 2015; 22 (6): 1005-1011.