Cause Sib cais thiab sib tham sib paj hlwb
Kev haus luam yeeb thiab kev haus ntau ua rau kev sib cais thiab kev sib raug zoo rau kev puas hlwb thiab kev ua haujlwm rau lub hlwb, xov xwm phem rau alcoholics, vim hais tias feem coob ntawm lawv yog neeg haus luam yeeb thiab.
Thaum Lub Ib Hli Ntuj 2005 lub rooj sib tham txhua xyoo ntawm Lub Koom Haum Tshawb Fawb Txog Dej Caw rau hauv Santa Barbara, California, ib qho kev sim tshuaj xyuas cov teebmeem ntawm kev haus luam yeeb thiab haus dej hauv hlwb hlwb thiab kev ua haujlwm.
Nyob rau hauv kev tshaj tawm xov xwm txog cov symposium, Dieter J. Meyerhoff, xib fwb ntawm kev tshawb fawb hauv University of California, San Francisco, tus kws tshawb fawb hauv Veterans 'Affairs Medical Center San Francisco, thiab lwm cov neeg koom nrog tau tshawb pom cov kev tshawb pom:
"Cov kev tshawb fawb tsis ntev los no txog cov kev haus luam yeeb tau qhia tias lub hlwb tsis muaj zog thiab ntshav khiav tsis zoo," said Meyerhoff, tus saib xyuas txoj haujlwm.
"Cov kev paub txog cov neeg haus luam yeeb tau raug tshaj qhia txog kev mloog lus thiab kev nco, kev cia siab rau yav tom ntej, kev ua hauj lwm nco, kev nrhiav pom, kev ceev nrig ntawm lub hlwb thiab kev txawj ntse, kev txawj ntse, thiab kev sib npaug," Meyerhoff said.
"Peb kuj ntseeg tias qhov teebmeem ntawm kev haus luam yeeb, ib yam li haus dej haus cawv, yuav siv ntau xyoo los ua rau lub hlwb muaj nuj nqi, thiab cuam tshuam nrog lub hnub nyoog los tsim ib theem ntawm kev ua haujlwm uas pom tseeb ntawm kev paub xeem."
"Txhua yam cwj pwm coj, xws li kev quav dej quav cawv los yog quav yees quav yeeb quav tshuaj, yog qhov tshwm sim ntawm kev sib koom tes ntawm lub cev," said co-author Yousef Tizabi. "Cov tshuaj, xws li cawv thiab nicotine , tuaj yeem cuam tshuam lwm tus neeg txawv raws li lawv cov caj ces tshuaj.
"Yog li, kev haus luam yeeb thiab kev haus luam yeeb yuav raug txiav txim siab yog qhov kawg ntawm noob caj noob ces, ib puag ncig, thiab kev sib koom tes tshuaj yeeb ntawm cov dej cawv thiab nicotine."
Sib npaug ntawm seem
"GABA yog ib qho tshuaj tiv thaiv cov kab mob hauv hlwb hauv tib neeg lub hlwb thiab yog qhov tseem ceeb hauv kev sib txeeb ntawm kev lom neeg ntawm cov tshuaj amino acid glutamate," explained Meyerhoff. "Thaum lub cev tsis muaj cawv, GABA muaj ntau ntxiv, tab sis qhov kev sib txawv ntawm cov phais yog tseem qis.
" Benzodiazepines yuav ua rau cov lus teb ntawm (GABA) Ib tug neeg txais tos rau GABA thwj toob, yog li muaj kev txuam ntxim rau tus neeg siv."
Ntau dua lub hlwb txawv txav
"Peb kawm recent detoxified alcoholics nyob rau hauv kev kho mob siv magnetic resonance hauv-vivo," said Meyerhoff. "Qhov kev siv peb tau siv yog magnetic resonance imaging (MRI), uas ntsuas qhov loj ntawm ntau lub paj hlwb, thiab magnetic resonance spectroscopic imaging (MRSI), uas ntsuas qee yam tshuaj tshwm sim hauv lub hlwb uas qhia peb txog kev raug mob rau lub hlwb hlwb.
"Peb cov kev soj ntsuam pom tau hais tias kev haus luam yeeb muaj ceem ntau dua uas muaj lub hlwb txawv txav - uas yog, tsis muaj lub paj hlwb ntawm ntsuas MRI, thiab ntau lub hlwb raug ntsuas los ntawm MRSI - thaum pib ntawm kev kho mob rau kev quav dej quav cawv dua li tsis haus luam yeeb haus cawv . Thiab ob pab pawg muaj ntau lub hlwb txawv tsis dua tus neeg haus luam yeeb lub teeb. "
Cuam tshuam kev kho mob Metabolite
"Peb pom tias qhov tseem ceeb ntawm ob lub paj hlwb metabolite ntawm kev lag luam ntawm lub xov tooj ntawm tes thiab lub parietal lobes ntawm recovering alcoholics," said co-author Timothy Durazzo. "Rau feem ntau hauv cheeb tsam lub hlwb, cov kev nce no tau tshwm sim hauv cov neeg haus luam yeeb tsis haus luam yeeb , tsis haus luam yeeb recovering alcoholics , uas qhia tias kev haus luam yeeb ntev yuav tuaj yeem cuam tshuam txog kev noj cov tshuaj metabolit.
"Nws muaj peev xwm hais tias pheej haus luam yeeb hauv kev haus dej caw thaum lub sij hawm luv luv ua rau lub plhu loj thiab tsis muaj zog ntawm cov kab mob tsis haum thiab, nrog rau carbon monoxide raug mob thiab tej zaum yuav txo hlwb paj hlwb, tej zaum yuav cuam tshuam lub hlwb cov ntaub so hauv kev haus luam yeeb hauv kev haus luam yeeb recovering alcoholics. "
Grey Matter Loss
"Peb cov qhab-nees MRI ntau tau qhia txog kev haus dej caw thiab haus luam yeeb ob leeg yog txuam nrog cortical gray teeb meem," said Meyerhoff. "Qhov no ua rau atrophy, uas feem ntau yog qhov zoo tshaj rau cov uas muaj feem cuam tshuam thoob ntiaj teb thiab lub hlwb tsis nco qab thiab, yog tshwm sim hauv nruab nrab lub hnub nyoog, yuav ua rau kom muaj kev pheej hmoo rau kev paub yav dhau los thiab paub ntau dua cov laus .
"Yog li, haus luam yeeb cawv, tshwj xeeb yog cov neeg uas muaj hnub nyoog 40 xyoo lossis tshaj saud, tej zaum yuav ua rau lawv tus kheej pheej hmoo ntau dua rau txoj kev xav tsis meej nrog rau hnub nyoog."
Source : Symposium kev tshawb nrhiav tau luam tawm nyob rau lub Ob Hlis 2006 qhov teeb meem ntawm Alcoholism: Clinical & Experimental Research .