Cawv Cov Cim Txheej Txheem Kev Tsim Nyog Osteoblasts
Ntawm tag nrho cov kev tshwm sim ntawm hnyav ntev cawv siv, tej zaum qhov tsawg paub yog qhov hnyav ntau npaum li cas yuav muaj feem cuam tshuam tus pob txha hauv lub cev.
Kev tshawb fawb pom tau hais tias kev haus dej cawv thiab hnyav ntau tuaj yeem ua rau cov pob txha tsis tshua muaj zog, nce pob txha thiab qeeb hauv kev kho pob txha, tab sis cov kev tshawb fawb tau ua los ntawm kev haus cawv ntawm cov pob txha tshiab.
Txoj kev loj hlob thiab kev ua haujlwm ntawm osteoblasts, hlwb pob txha tshiab, yog qhov kev pheej hmoo ntawm kev haus dej cawv los ntawm cov dej cawv, uas tuaj yeem ua rau cov pob txha tsis muaj zog thiab cov pob txha tsis tshua muaj.
Cov neeg tshawb nrhiav ntawm Omaha Veterans Affairs Medical Center pom tau hais tias mob ntev thiab hnyav haus tau ua rau hauv cov osteoblasts.
Cawv Cuam Tshuam Kab Npaum Kho
"Tus saib xyuas kev noj qab haus huv pob txha hauv tib neeg laus tshwm sim los ntawm tus txheej txheem hu ua 'txha caj npab,' hais tias Dennis A. Chakkalakal, ib tug kws tshawb fawb ntawm Omaha Veterans Affairs Medical Center, associate professor nyob rau hauv chav haujlwm ntawm kev phais ntawm Creighton University, thiab tib leeg sau ntawm kev ntsuam xyuas. "Lub sijhawm twg los tau thaum laus neeg lub neej, thiab nyob rau ntau qhov chaw ntawm lub cev pob txha, feem ntau ntawm cov laus pob txha raug muab tshem tawm ntawm cov hlwb hu ua" osteoclasts, "thiab pob txha tshiab yog tsim los ntawm hlwb hu ua 'osteoblasts. Nyob rau hauv ib tug neeg noj qab haus huv, ob txoj kev ua si yog nyob rau hauv sib npaug thiaj li tsis muaj net poob ntawm tus pob txha. "
Txawm li cas los xij, Chakkalakal tau qhia tias mob ntev thiab hnyav tau cuam tshuam tau qhov kev tshuav ntawm suppressing tus pob txha tshiab.
"Qhov chaw npliag tsim los ntawm kev ua pob txha hauv kev ua pob txha tsis zoo yog tsim tsis tau los ntawm cov pob txha tshiab tshiab," said Chakkalakal. "Txoj kev no tseem nyob rau lwm qhov chaw skeletal thaum lub sij hawm hloov tshiab tom ntej.
Qhov cumulative cov nyhuv ntawm cov txheej txheem no thaum lub sij hawm ob peb qhov kev hloov kho tau pom tau tias yog tus pob txha ntsuas tau ntau tshaj li ntawm ob peb xyoos. "
Ntxiv Puas Tseg
Cov ntsiab lus tseem ceeb ntawm kev kawm Omaha muaj xws li:
- "Tus kab mob uas muaj cawv cawv " yog hais txog ob lub tswv yim ntawm kev quav dej quav cawv ntxiv : pob txha txha (kuj paub osteopenia), uas ua rau muaj kev phom sij ntxiv zuj zus; thiab kho pob txha tsis zoo.
- Cawv hws osteopenia yog qhov txawv ntawm cov menopausal osteoporosis tom qab thiab ua rau tsis muaj kev txhawj xeeb.
- Cov kev tshawb fawb ntawm tib neeg, tsiaj txhu thiab kab lis kev cai ntawm kab lis kev cai qhia tau hais tias haus dej cawv muaj teebmeem rau kev ua haujlwm osteoblast yog cov tshuaj tua kabmob.
- Cawv muaj peev xwm suppress synthesis ntawm matrix ossifiable, uas cuam tshuam nrog pob txha kho.
- Cov pob txha cawv qaub ncaug vim yog txuam nrog kev txawv txav ntawm cov kab mob hauv lub hlwb hauv pob txha pob txha.
Cawv cuam tshuam osteoblast kev ua ub no
"Sau hais lus, pov thawj qhia tias muaj ib qho xov uas sib raug zoo ua ke nrog pob txha caj qaum, xws li cov pob txha tsis zoo thiab cov pob txha kho tsis zoo, thiab haus tau ntev ntawm ntau cawv ," Chakkalakal said.
"Hauv ob qho tib si, haus dej cawv cuam tshuam osteoblast yam, yog li suppressing tus pob txha tshiab tsim nyog hauv ob qho tib si qub pob txha kho thiab tawg puas," nws hais.
"Peb xav tau cov kev tshawb fawb yav tom ntej uas yog xav txog cov txheej txheem ntawm cov dej cawv uas muaj cawv cwj pwm cuam tshuam osteoblast kev ua haujlwm Peb tseem xav tau kev soj ntsuam ntawm lwm yam xws li kev tsis noj nqaij, kev haus luam yeeb thiab tsis muaj kev ua ub ua no vim muaj ntau cov kev tshawb fawb uas soj ntsuam cov teeb meem ntawm tej yam zoo li no. "
"Thaum kawg, peb xav tau ntau yam kev tshawb fawb, tsim cov kev tshawb fawb kom paub cov hnub nyoog- thiab cov poj niam txiv neej sib txawv hauv cov teebmeem ntawm ntau yam thiab haus cawv ntau," Chakkalakal said.
Abstinence Qhov Kev Xaiv Pheej Zoo Tshaj Lij
"Txoj kev ntsuam xyuas pom tias tseem ceeb ntawm kev haus dej haus cawv siv los ntawm cov neeg mob - haus cawv los yog tshuaj tua kabmob - nrog cov pob txha thiab leej twg xav haus thaum lub caij lawv cov neeg tsis sib haum," said VA Research Career Scientist Terrence M.
Donohue, Jr.
Qhov chaw:
Chakkalakal, DA. "Cawv Cov Tsum Tau Txaus Ntse thiab Kho Cov Pob Txha Uas Tsis Tau Khaws." Alcoholism: Soj ntsuam & Kev tshawb nrhiav kev ntsuam xyuas lub Kaum Ob Hlis 2005