Txoj Kev Kawm Tshaj Tawm Yuav Qhia Tau Coj Tus Cwj Pwm Coj Ncaj Ncees hauv Qee tus Neeg Haus Dej
Txawm tias feem ntau cov kev tshawb fawb tau pom tias cov dej cawv txwv tsis pub cov qaub qaub ntawm testosterone, nws muaj ib txoj kev tshawb nrhiav pom tias haus cawv muaj peev xwm qee zaum ua rau mob plasma thiab hlwb ntau ntawm cov testosterone.
Qhov kev tshawb nrhiav no, qee qhov qaug dej cawv yuav nce siab rau testosterone nyob rau hauv lub hlwb rau qee cov tib neeg, yuav piav qhia tias vim li cas haus dej caw ua qee cov neeg ua neeg txhawj xeeb thaum qaug.
Nws kuj tseem piav qhia txog qee qhov lwm cov kev coj cwj pwm uas muaj feem xyuam nrog ntau ntxiv testosterone, xws li kev ua kom muaj libido, cov kws sau ntawv pom zoo.
"Peb tau pom hais tias muaj ntau hom kev sib txawv ntawm ob hom kev sib txawv ntawm cov txiv neej tus kab mob testosterone tom qab mob haus cawv," said Robert H. Purdy, ntawm Scripps Research Lub koom haum thiab tus neeg sau tsab ntawv no. "Cov kev sib txawv ntawm cov tsiaj no yuav muaj kev sib txawv ntawm cov tib neeg sib txawv, thiab muab cov kev nkag siab tshiab rau kev to taub cov tib neeg sib txawv hauv txoj kev coj tus cwj pwm thiab txoj kev xav ntawm kev quav yeeb quav cawv nrog kev haus cawv ."
Neuroactive Steroids Ntsuas
Raws li daim ntawv tshaj tawm: Cov neeg tshawb xyuas "txhaj tshuaj cawv los yog 1,1-dideuteroethanol (2 g haus dej cawv / kg lub cev hnyav) rau cov kabmob plab ntawm ob pawg cov nas, 30 tsis ua haujlwm thiab 24 adrenalectomized thiab castrated (ADX / GDX) Wistar txiv neej.
1,1-dideuteroethanol yog ib hom yeeb yaj kiab uas tsis muaj dej haus cawv uas muaj ob hom tshuaj hydrogen hauv carbon atom # 1 ntawm ethanol tau hloov los ntawm cov kab mob deuterium, uas tau ces yuav tau siv. "
Lawv mam li siv huab hwm coj spectrometry los txiav txim ob qho tib si ntawm cov neuroactive steroids thiab cov degree ntawm deuterium nyob rau hauv cov kev txwv cov kab mob neuroactive steroids ntawm lub paj hlwb.
Fourfold nce hauv Testosterone
Cov neeg tshawb fawb tau pom tias cov concentrations ntawm testosterone ntau dua plaub ciam nyob rau ntawm lub hauv ntej cortex thiab threefold hauv plasma ntawm cov nas tsis ua hauj lwm 30 feeb tom qab haus dej cawv.
ADX / GDX nas muaj testosterone ntau npaum li tsib feem pua ntawm cov neeg nyob hauv cov nas tsuag tsis tau tom qab haus dej cawv. Cov kev tshawb pom pom tias oxidation cawv ncaj qha mus txuas rau testosterone biosynthesis, cov sau phau ntawv hais.
Direct Cawv-Testosterone Txuas Tshaj Tawm
"Peb pom ntawm kev sib txuas ncaj nraim ntawm kev tswj dej haus cawv thiab theem ntawm cov tshuaj tua kab mob hauv cov hlwb hauv cov hlwb ntawm cov kev sim no yog tsis tau los ntawm cov kev tshawb fawb ua ntej nrog lwm hom nas," Purdy said.
"Txawm hais tias muaj ntau yam kev tshawb fawb pom tseeb hais tias kev noj haus ntau ntawm kev haus dej haus cawv tuaj yeem tshwm sim tsis zoo thiab ua kom tsis muaj kev ua haujlwm," said Dennis D. Rasmussen, xibfwb kev tshawb fawb hauv cov koom haum ntawm kev puas hlwb hauv University of Washington, "qhov kev tshawb kawm no nce qhov tseem ceeb ntawm lub sijhawm ntawm kev haus dej cawv kuj tseem tuaj yeem mob qis dua ib ntus testosterone, nrog rau kev taw qhia ntawm cov lus teb yuav yog nyob ntawm ntau yam, nrog rau kev siv tshuaj thiab tus yam ntxwv. "
Yog li, kev haus dej haus cawv, yam tsawg kawg ntawm qee qhov kev mob thiab tsawg kawg yog qee tus neeg, tej zaum yuav ua rau tus mob siab plawv thiab hlwb ntawm ob tug txiv neej thiab pojniam niam txiv qee yam ntawm kev coj tus cwj pwm txuam nrog ntau zog testosterone, xws li kev ua rau libido nce lossis kev ua phem . "
Lub luag haujlwm ntawm Testosterone thiab Cawv Cov Teebmeem
Txoj kev tshawb nrhiav cov lus tshawb tau koom nrog ob ntawm lwm cov kev tshawb fawb ntawm cov dej cawv khiav dej ntau ntxiv cov ntshav siab testosterone theem ntawm cov poj niam txiv neej thiab cov kab mob raws li nws.
"Ua ke cov kev tshawb fawb no tseem ceeb heev," nws hais tias, "vim lawv qhia hais tias tau ua li cas thiaj li tau txais kev coj zoo - uas haus dej cawv ua rau cov ntshav plawv thiab cov ua haujlwm tsis muaj txiaj ntsig - tsis yog universally tseeb."
Rasmussen pom tias yav tom ntej tshawb fawb ntxiv thiab ntxiv rau cov kev tshawb pom yav dhau los hais txog kev haus cawv los ntawm testosterone.
Puas kam tuaj yeem tsim tawm ntev tshaj?
"Nws yog ib qho tseem ceeb los txiav txim seb puas pes tsawg cov dej cawv , uas tsis ua rau qee zaum qaug qaug zog thiab ataxia, kuj yuav ua rau mob loj zuj zus hauv testosterone, thiab seb qhov lus teb rau qis qis dua yuav zoo ib yam txawv ntawm cov nas tsuag. puas kam ua kom loj hlob nrog cov kev khiav dej num rov qab? " nws nug.
"Puas yog qhov nce hauv testosterone tshwm sim tom qab xaiv tus kheej tswj kev haus cawv?" Rasmussen tau hais. "Thaum kawg, thiab feem ntau yog qhov nthuav dav, qhov kev yuav ua rau cov kev hloov hauv testosterone ua si hauv kev coj cwj pwm mus rau kev noj haus ethanol puas muaj cov poj niam sib txawv hauv cov lus teb no thiab, yog tias cov lus teb tshwm sim rau cov poj niam, lawv puas txawv thaum sib txawv ntawm tus poj niam lub voj voog? "
Source:
Alomary, AA, li al. "Acean Ethanol koom rau hauv Testosterone Synthesis thiab Tsub kom Muaj Testosterone hauv Nroj Hlwb." Alcoholism: Soj ntsuam & Kev tshawb nrhiav kev ntsuam xyuas lub Ib Hlis Ntuj 2003