Lub Scarce Science Qab Qhov Calcium Channel Blocker
Verapamil, ib hom calcium channel blocker, tau kawm xyoo dhau los ua ib txoj kev kho rau cov kev mob tshwm sim hauv cov neeg uas muaj kev puas siab puas ntsws bipolar. Uas tau hais tias, cov ntaub ntawv ntawm qab nws yog scarce thiab controversial, qab hau tej kev tshawb fawb tau pom ib qho kev pab thiab lwm tus tsis muaj. Txawm li cas los xij, nws tsis yog ib qho kev siv los yog tus qauv siv los ntawm cov kws kho mob hauv kev kho tus mob bipolar .
Cia peb kuaj cov keeb kwm tshawb fawb tom qab siv cov tshuaj verifamil thiab lwm yam calcium channel blockers hauv kev puas siab puas ntsws bipolar.
Dab tsi yog Calcium Channel Blockers?
Calcium channel blockers cuam tshuam lub zog ntawm calcium hauv hlwb ntawm lub plawv thiab cov hlab ntsha, relaxing cov hlab ntsha thiab ua rau cov ntshav thiab cov pa oxygen rau lub plawv. Lawv feem ntau yog siv los kho ntshav siab, arrhythmia (lub plawv dhia tsis xwm yeem) thiab angina pectoris (lub plawv mob hauv plawv).
Calcium channel thaiv thaiv cov kab mob tseem ceeb uas tau kuaj pom tias kev kho mob rau kev puas siab puas ntsws bipolar, tshwj xeeb tshaj yog cov kev mob tshwm sim muaj xws li:
- Verapamil - hom npe Calan, Isoptin SR
- Nimodipine - hom npe Nimotop
- Diltiazem - hom npe Cardizem, Cartia XT, Dilacor XR, Tiazac
Verapamil
Hais txog nws qhov txiaj ntsim, ib qho kev tshawb fawb 2002 hauv Biological Psychiatry tau soj ntsuam 11 cov poj niam uas muaj kev tswj xeeb los yog muaj kev ntxhov siab ntawm kev nyuaj siab thiab kev tswj siab.
Ntawm cov pojniam 11, 9 leej pom tau zoo lossis kev txhim kho hauv lawv lub cev tom qab raug kho nrog verify.
Hauv ib txoj kev tshawb fawb txog 2008 hauv Bipolar Disorders, verify tau ib leeg tsis zoo dua qub, tab sis thaum ua ke nrog lithium, nws ua li ntawd. Uas tau hais tias, txoj kev tshawb no tseem tsawg, nrog tsuas yog 10 cov neeg mob ua ke ntawm verapamil thiab lithium.
Tus neeg sau ntawv tau sau tseg tias ib tug neeg twg uas tau siv cov lus qhia ua ke ntawm verify thiab lithium yuav tsum tau saib xyuas zoo, vim tias muaj kev phom sij xws li:
- ua rau muaj kev phom sij los ntawm kev phais
- choreoathetosis - tsis tuaj yeem hloov
- qeeb plawv dhia nrog lub plawv nres
- teeb meem nrog kev sib koom tes
Nimodipine
Ib xyoo 2002 kev tshawb fawb hauv American Journal of Obstetrics thiab Gynecology tau qhia txog kev siv cov tshuaj muaj kuabis zoo hauv cov poj niam cev xeeb tub. Nws tsis muaj peev xwm zam tau ntau dua ib txwm lub siab ruaj ruaj, lithium.
Tsis tas li ntawd, raws li txoj kev tshawb fawb hauv Bipolar Teeb Meem , pab tau cov neeg muaj kev puas siab puas ntsws bipolar tsis tuaj yeem tiv thaiv kev noj tshuaj, tshwj xeeb tshaj yog cov neeg uas muaj kev kub ntxhov ceev thiab cov kev mob ntsws rov tshwm tuaj.
Diltiazem
Nyob rau hauv ib txoj kev tshawb xyuas me me 2000 hauv phau ntawv Journal of Psychiatry and Neuroscience, ntawm yim tus neeg mob uas muaj kev puas siab ntsws los tiv thaiv kev puas siab puas ntsws bipolar, muaj kev txo qis dua ob lub plawv thiab kev nyuaj siab mob tom qab siv tshuaj tua kab mob. Uas tau hais, muaj teeb meem nrog cov qauv ntawm txoj kev tshawb no. Piv txwv li, cov neeg mob tau noj lwm yam tshuaj tsis yog diltiazem, thiab nws me me.
Dab Tsi Tag Nrho No?
Nws yog ib qho tseem ceeb kom to taub tias cov tshuaj calcium channel blockers tsis yog cov tshuaj noj rau kev noj qab haus huv - ua pov thawj los ntawm qhov tseeb tias muaj ob peb cov kev tshawb fawb rau lawv.
Nrog rau qhov no, nws tsis totaub ntawm lub sijhawm no lub sijhawm ua haujlwm zoo li cas ntawm cov txiaj ntsig ntawm calcium channel blockers yuav kho tus mob ntawm kev puas siab puas ntsws bipolar. Tej zaum nws yuav yog siv nrog lwm cov cwj pwm tsis txaus siab thaum ib tus neeg tsis tuaj yeem tiv thaiv lub siab tawv ib leeg los yog lwm cov kev sib txuas ntawm cov tshuaj.
Qhov chaw:
Dubovsky SL, Franks RD, Allen S, & Murphy J. Psychiatry Res. 1986 Aug; 18 (4): 309-20.
Goodnick PJ Kev siv cov cimodipine hauv kev kho mob hauv lub siab. Bipolar Disord. 2000 Sep; 2 (3 Pt 1): 165-73.
Mallinger AG li al. Verapamil augmentatin ntawm kev kho cov tshuaj lithium ua rau cov kev ua tau zoo dua nyob rau hauv mania tsis nco qab txog lithium ib leeg: qhov kev tshawb pom thawj zaug thiab kev sib tham ntawm cov tswv yim kho mob. Bipolar Disord . 2008 Dec; 10 (8): 856-66.
Silverstone PH & L. Birkett. Diltiazem ua qhov kev tu mob hauv cov neeg mob uas muaj kev puas tsuaj rau kev puas siab ntsws bipolar: ib txoj kev tshawb nrhiav retrospective. J Psychiatry Neurosci. 2000 Mai; 25 (3): 276-80.
Wisner KL li al. Verapamil kho rau cov poj niam uas muaj kev puas siab puas ntsws bipolar. Biol Psychiatry. 2002 Tsib Hlis 1, 51 (9): 745-52.
Yingling DR, Kws G, Vengalil S, & Mason B. Calcium channel blocker, nimodipine, rau kev kho mob ntawm kev puas siab puas ntsws bipolar thaum cev xeeb tub. Kuv J Obstet Gynecol . 2002 Dec; 187 (6): 1711-2.