Orexin yuav yog qhov tseem ceeb rau kev kho mob tshiab
Orexin, hu ua hypocretin, yog ib qho neurotransmitter tau pom nyob rau hauv 1998 uas yog ua rau thaj tsam hypothalamus ntawm lub hlwb uas muaj kev cuam tshuam nrog kev vam meej thiab kev txhawj xeeb.
Vim nws lub luag hauj lwm ntsig txog kev pw tsaug zog, orexin tau raug tsom li kev kho mob rau kev pw tsaug zog. Cov tshuaj hu ua "orexin receptor antagonists" tau raug tsim los thaiv cov tshuaj ntawm cov tshuaj hauv lub hlwb kom txhawb zog.
Vim hais tias orexin plays lub luag hauj lwm rau hauv kom peb sawv thiab ceev faj, thaiv qhov teebmeem nws yuav ua tau zoo dua qub. US Food and Drug Administration tau pom zoo tso cai suborexant (Belsomra), yog ib tug kws kho mob los yog ib tug neeg tuag tes taw, los yog tsaug zog.
Tam sim no cov kws tshawb fawb pom tau hais tias cov neeg muaj npe hauv plab kuj tseem tuaj yeem ua lub luag haujlwm hauv kev nrhiav nyiaj, kev rov qab tshuaj, thiab kev quav tshuaj thiab yog li ntawd yuav ua rau kev kho tshiab rau kev quav yeeb quav tshuaj.
Cov kws tshawb fawb pom tias cov keeb khaum ntawm cov hlab ntsha hauv lub hlwb tau txuas mus rau cov kev sib tw nrog txoj kev qhia tias cov neeg hloov kev sib tw no tuaj yeem ua lub luag haujlwm thiab kev txhawb zog siab.
Penn State kws tshawb fawb Glenda Harris, PhD, ua haujlwm nrog Gary Aston-Jones, PhD, hauv Department of Psychiatry, tshawb xyuas qhov kev sib raug zoo ntawm kev cog qoob loo thiab nqi zog ntawm kev tshawb fawb los ntawm kev tshawb fawb los ntawm kev noj qab nyob zoo hauv kev siv tus cwj pwm kev coj noj coj ua- thiab tshuaj yeeb-tshuaj nrhiav thiab siv yeeb tshuaj.
"Tus lateral hypothalamus tau raug khi rau nqi zog thiab kev zoo siab rau ntau xyoo, tab sis qhov kev cog qoob loo thiab cov tshuaj uas muaj feem xyuam tau muaj kev tsim txiaj," says Aston-Jones.
"Qhov no yog thawj qhov qhia txog tias neuropeptide orexin yog ib qho tseemceeb hauv kev nrhiav txiaj ntsim thiab kev siv yeeb tshuaj , cov txiaj ntsim zoo tshaj plaws no yog tsim los qhia txog kev tshiab, kev rog, thiab lwm yam kev mob uas muaj feem nrog kev ua haujlwm tsis zoo.
Cov soj ntsuam ntawm pom tias muaj kev sib txuas ntawm kev ua kom muaj zog ntawm orexin neurons nyob rau hauv cov lateral hypothalamus thiab nqi zog nrhiav cov morphine, yeeb dawb , thiab zaub mov.
Lawv pom tias cov kev ua haujlwm siab tshaj plaws hauv cov orexin neurons tshwm nyob rau hauv cov nas tsuag uas qhia ntau tshaj qhov nqi zog nrhiav.
Txoj Phuam Tsom Kwm Tshaj Tawm thiab Tawm
Txoj kev tshawb no tau qhia ib qho kev sib koom tes ntawm kev sib koom tes thiab cov nqi zog ntawm cov nas nyob hauv peb txoj hauv kev:
- Kev ua rau cov leeg orexin neurons muaj feem xyuam rau cov kev nyiam los ntawm cov nas tsuag rau cues cuam tshuam nrog tshuaj yeeb thiab khoom noj khoom haus
- Kev siv tshuaj ua los ntawm orexin neurons rov ua dua ib qho kev haus cwj pwm tshawb nrhiav yeeb tshuaj
- Txoj kev txhaj tshuaj los ntawm orexin rov ua kom coj tus cwj pwm coj.
Ntxiv rau, thaum cov neeg tshawb xyuas tau muab cov nas tsuag rau ib qho kev ua los ntawm cov tshuaj tua kab mob, los yog cov tsiaj pib qhov kev nyiam tshuaj thiab kev rov ua kom rov tua tus yeeb tshuaj.
Kev Tshawb Fawb Kev Raug Tsim Nyog Raug Tshem Tawm
"Vim txoj kev sib raug zoo ntawm kev ua kom khov thiab ua kom rov nrhiav dua tshiab, qhov kev tshawb pom no yuav muaj qhov cuam tshuam rau kev to taub txog kev siv tshuaj yeeb dej caw rau tib neeg," cov kws tshawb fawb tau sau. "Tus tsiaj lub nqi zog nrhiav tau muab tua tau thaum lub sij hawm los ntawm qhov ua kom rov tua cov tsiaj mus rau qhov chaw muaj cov yeeb tshuaj cuav uas tsis muaj yeeb tshuaj yav dhau los."
"Tom qab tua hluav taws nrov, nrhiav tau ib qho stimulus uas yav dhau los txuam nrog cov tshuaj yuav ua rau tsiaj txhu rov qab pib nqi zog nrhiav, zoo ib yam li thaum tib neeg muaj kev rov qab tshuaj," lawv hais.
Lub Hom Phiaj Tshiab Ntxiv Rau Txoj Kev Kho Mob
Siv cov neuropeptide uas ua rau cov leeg khaus losyog cov leeg hlwb nyob rau hauv cov lateral hypothalamus, Harris thiab cov npoj yaig tuaj yeem rov tuaj yeem rov nrhiav cov tshuaj nrhiav hauv cov nas uas tshuaj yeeb-tshuaj nrhiav tau yav tas los lawm.
"Cov kev tshawb pom no qhia txog txheej tshiab ntawm neurons thiab cov kab mob neuronal receptors uas yog qhov tseem ceeb ntawm kev ua khoom plig rau cov khoom noj," says Aston-Jones. "Qhov no muab ib lub hom phiaj tshiab los tsim kev siv yeeb tshuaj los kho cov kab mob kev ua lag luam xws li kev quav dej quav cawv thiab haus cawv , kev haus luam yeeb, thiab kev rog."
Cov chaw
Ebrahim, IO, li al. "Hypocretin / orexin system." Phau ntawv Journal ntawm lub noob nom noob tswv Koom Haum Zej Tsoom May 2002
Harris, GC li al. "Lub luag hauj lwm rau lateral hypothalamic orexin neurons hauv nqi zog nrhiav." Xwm Cuaj hlis 22, 2005
National Sleep Foundation. "Orexin receptor antagonists: Ib chav kawm ntawv tshiab ntawm kev ntsiav tshuaj." Cov xov xwm pw tsaug zog