Xav tias koj yuav tau txais ib qho tshuaj txhaj tiv thaiv uas yuav tiv thaiv koj ntawm kev tiv thaiv nicotine . Tom qab tau txais koob tshuaj tiv thaiv kab mob uas txhawb koj lub cev tsim cov tshuaj tiv thaiv kab mob nicotine, qhov tshuaj tiv thaiv no yuav ua rau cov tshuaj tsis yog hom tshuaj.
Txawm hais tias nws yuav zoo li tsis tshua muaj nqis, xws li tshuaj tiv thaiv tam sim no nws tseem nyob hauv kev txhim kho. Yav tas los tshawb xyuas los ntawm cov neeg soj ntsuam ntawm Nabi Biopharmaceuticals nyob rau hauv lub npe ntawm NicVax, Nabi tau txais $ 10-lab nyiaj pab hauv 2009 los ntawm National Institute rau Txoj Kev Phom Yeeb, ib feem ntawm National Institutes of Health yuav tsiv mus nrog rau thawj ob theem III sim.
Hmoov tsis, thaum Lub Xya Hli ntawm 2011, lawv tau qhia txog kev xav tau, tias thawj theem III sim tau ua tsis tiav, nrog tsuas yog 30% ntawm cov neeg mob pom qhov ntsuam xyuas. Thaum lub Kaum Ib Hlis xyoo tib lub xyoo, lawv tshaj tawm hais tias qhov thib ob theem III sim tau ua tsis tiav, nrog qhov tshuaj tiv thaiv ua tsis zoo dua li cov placebo.
Yuav Ua Li Cas Cov Tshuaj Tiv Thaiv Ua Haujlwm
Thaum ib tus neeg twg tau txhaj koob tshuaj tiv thaiv kab mob, qhov txhaj tshuaj no muaj qee yam ntawm cov kab mob uas muaj hom kab mob los yog cov kab mob hauv lub xeev tsis muaj zog los yog tuag lawm. Thaum nkag rau hauv lub cev, lub cev tsis muaj zog pom thiab tsim cov tshuaj tua kab mob uas ua kom puas lossis tua tsis tau cov kab mob ua kom tsis zoo. Nyob rau hauv no txoj kev, lub cev npaj tawm tsam tawm tsam ntawm tus kab mob nyob los yog kab mob, yog tias nws tshwm sim.
Qhov tshuaj tiv thaiv tus kab mob Nicotine yog tsim los ua haujlwm
Nicotine molecules yog ib qho me me thiab txav tau yooj yim los ntawm cov ntshav-hlwb barrier, qhov chaw uas lawv khi rau nicotine receptors uas qhib cov khoom plig rau hauv lub hlwb, ua rau theem ntawm dopamine . Dopamine yog ib tug neurotransmitter uas yog lub luag haujlwm rau kev xav ntawm kev lom zem, kev noj qab nyob zoo, thiab kev vam.
Nws yog tus txheej txheem no uas tau xav tias yog nyob hauv lub hauv paus ntawm txoj kev tiv thaiv lub cev.
Tshuaj nicotine txhaj rau lub cev los tua cov nicotine. Nws ua qhov no los ntawm kev siv cov nicotine haptens hauv cov ntshav dej. Haptens yog cov lwg me me uas txhawb nqa antibody ntau thiab attraction thaum ua ke nrog ntau cov protein ntau molecules.
Thaum cov tshuaj tiv thaiv cov hlab ntsha ntawm kev txhaj tshuaj ntawm caj npab, lub cev reacts rau cov haptens los tsim cov tshuaj tiv thaiv kab mob nicotine. Cov tshuaj tiv thaiv "ces" nicotine molecules los ntawm kev ruaj ntseg nrog lawv. Vim tias cov tshuaj tiv thaiv (thiab nrog cov nicotine molecules) ua ke loj heev rau kev ua txhaum cov ntshav / lub hlwb, cov nicotine tsis tuaj yeem taug kev mus rau lub hlwb uas nws muaj peev xwm ua rau dopamine tso tawm.
Tsis muaj dopamine, cov neeg haus luam yeeb tsis txaus siab rau kev haus luam yeeb thiab qhov txuas rau lub cev tiv thaiv kev tu ncua.
Kev tshuaj ntsuam nicotine tam sim no
Cov neeg tshawb nrhiav ntawm Lub Koom Haum Scripps Research Center (TSRI) ua hauj lwm ntawm kev tsim muaj tshuaj tiv thaiv kab mob nicotine ntau heev thiab pom cov lus qhia txhawb kom lawv nyob ntawm txoj kev yog.
Raws li xib fwb ntawm Science News for KIDS ntawm TSRI, Kim Janda, muaj ob hom nicotine uas yog daim iav duab ntawm ib leeg, "laug-handed" thiab "cai-tes" molecules, yog tias koj xav tau. Lub nicotine hauv luam yeeb yog yuav luag tag nrho ntawm cov laug-tes ntau. Cov tshuaj tiv thaiv kab mob ntsig txog Nicixe tau ua los ntawm ob qho tib si uas tau nicotine thiab cov nicotine uas tau tso cai thiab tsis yog tshuaj tiv thaiv kab mob.
Cov kws tshawb nrhiav ntawm TSRI tau tsim peb hom tshuaj tiv thaiv: 50/50 mix ntawm ob hom nicotine, thiab cov ntshiab txoj kev ntshiab thiab ntxuav tawm ntawm cov tshuaj tiv thaiv.
Hauv kev ntsuam xyuas kev kuaj hauv cov nas, lawv nrhiav tau tias 50/50 mix tsuas yog 60 feem pua uas ua tau zoo raws li cov tshuaj tua kab ntshiab uas tso tawm.
"Qhov no qhia tias cov tshuaj tiv thaiv kab mob yav tom ntej yuav tsum npaj hom phiaj uas tau tso tseg," said Jonathan Lockner nyob rau hauv xovxwm 2015 tso tawm los ntawm lub koom haum. Lockner yog ib tug neeg tshawb nrhiav nyob hauv Janda (lab).
Kev tshawb nrhiav tab tom tab sis zoo nkaus li kev cog lus rau yav tom ntej.
Koob tshuaj nicotine, yog tias tau pom zoo, yuav yog ib qho tseem ceeb ntxiv rau ntau hom kev pab cuam tawm hnub no. Muaj ib tug neeg lub neej raug ploj mus rau cov kab mob kev nkeeg txhua 8 vib nas this ntawm ib qhov chaw hauv ntiaj chaw, cov neeg haus luam yeeb yuav tsum muaj ntau txoj hau kev kom pab tau lawv ntaus cov yeeb tshuaj nicotine ua ntej lawv ntaus lawv.
Source:
Lub Scripps Research Lub koomhaum. TSRI Cov Neeg Kawm Tsim Hom Tshuaj Nicotine Uas Kho Cov Kev Pabcuam Robust Txhaj Tshuaj. http://www.scripps.edu/news/press/2015/20150112janda.html. Tau txais lub Ob Hlis 2016.
Nabi Biopharmaceuticals. Nabi Biopharmaceuticals Initiates Pivotal Phase III Kawm rau NicVAX ua Kev Pab Txiav Kev Haus Luam Yeeb thiab Kev Pluag Kom Ntev Mus ntev ntev http://phx.corporate-ir.net/phoenix.zhtml?c=100445&p=irol-newsArticleIID=1350155&highlight=. Tau txais lub Ob Hlis 2016.