Txhim Kho Cawv-Cwj Pwm Kev Coj Ncaj thiab Ua Siab
Cov kws tshawb fawb tau txuas cov protein tso tawm hauv lub hlwb mus rau cov cwj pwm tshawb nrhiav cawv thiab ua rau cov kev ntxhov siab ntawm kev quav cawv .
Cov kws tshawb fawb hauv University of Washington qhia txog thawj cov pov thawj hauv cov nas uas cov protein proteinasease A (PKA) qhia txog kev coj cwj pwm thiab kev coj cwj pwm rau qee yam ntawm kev quav dej quav cawv, raws li National Institute on Alcohol Abuse and Alcoholism.
Altered Teb
Thaum xaiv cov dej dawb thiab cov ntsiab lus muaj cawv, cov nas uas tsis tau koom hauv RIIB subunit ntawm PKA nyiam haus cov dej cawv los ntawm nws lub zog zoo tshaj plaws. Tsis tas li ntawd, cov qe cov ntshav tau ua rau cov neeg tsis muaj zog dua li cov PKA rau haus dej cawv.
Ib qho protein muaj feem rau hauv kev sib txuas lus hauv kev sib txuas lus, PKA yog nyob thoob plaws hauv lub hlwb. PKA phosphorylates ntau cov pob txhaws pob ntau heev thiab tswj cov noob qhia, hloov cov hluav taws xob ntawm lub xovtooj ntawm tes thiab, qhov muaj feem xyuam, ntawm tes thiab kev sib txuas lus ntawm cov neurons.
Cov neeg tsis muaj mob RIIB, ib yam ntawm cov noob qes uas yog encode PKA, muaj kev pauv hauv kev ua PKA, ib yam kev soj ntsuam ntawm ntseeg tias lawv hloov cov lus teb rau cov khoom siv yeeb tshuaj cawv.
Kev Haus Dej Cawv Siv
"Cov kev tshawb nrhiav yav dhau los hauv ob qho kev kuaj thiab tsiaj txhu tau qhia tias kev haus dej cawv muaj txiaj ntsim PKA ua haujlwm," said Enoch Gordis, MD, Tus thawj coj ntawm NIAAA, uas yog thawj qhov kev txhawb rau txoj kev tshawb fawb.
"Dab tsi tshiab txog kev ua hauj lwm no yog qhov rov qab - tias, yam tsawg kawg ntawm tus tsiaj qauv, PKA tswj cai haus dej cawv thiab qee yam ntawm kev haus cawv."
Todd Thiele, Ph.D., Department of Psychology thiab Alcohol and Drug Abuse Institute, University of Washington, thiab nws cov kwvtij txheeb xyuas cov cwj pwm haus hauv 12 tus nas thiab 12 lub poom pob muaj kev hloov nrog RIIb subunit ntawm PKA.
Whereas tsis muaj qhov sib txawv ntawm ob pawg neeg hauv kev nyiam saj rau lub ntsiab lus qab zib los sis kev tu siab, cov nas tsuag nrog PKA hloov dua li ob zaug kom ntau tshaj 20 feem pua ntawm cov cawv haus ua cov nas tsuag.
Sedative los
Cov neeg soj ntsuam kuj tau ntsuas lub sij hawm tsim nyog rau cov qe ntshauv mus qiv rau txoj kev rov qab txiav txim siab. Lawv tau txhaj ob hom nas ntawm cawv thiab tom qab ntawd lawv tso rau ntawm lawv cov nraub qaum hauv cov yas U-puab sab. Knockout nas zoo zoo sai dua los ntawm sedative teebmeem ntawm cawv, nws cov footing tom qab 65 feeb nrog piv li 90 feeb rau cov nas.
"Nws yuav hais tias cov nas tsuag nrog RIIB hloov ua ntau dua ethanol vim hais tias PKA yam cuam tshuam nyob rau hauv hlwb regions koom tes hauv mediating ethanol nqi zog," said Dr. Thiele. "Nws yog tam sim no tseem ceeb los txiav txim siab nyob rau hauv lub hlwb hauv cheeb tsam lub RIIB subunit ua cov teebmeem."
> Qhov chaw:
> Thiele, TE, li al. "High Ethanol Consumption thiab Low Sensitivity rau Ethanol Txheem Sedation hauv Protein Kinase A-Mutant Mice." Phau ntawv Journal of Neuroscience Tsib Hlis 2000