Dab tsi yog ib feem ntawm Dopamine Agonist?
Hauv tsab ntawv no, koj yuav kawm txog dopamine ib nrab agonism. Cov nyhuv no yog qhov zoo tshaj plaws los ntawm aripiprazole (hom tshuaj npe: Abilify), ib qho tshuaj tiv thaiv ob lub hauv siab / atypical neuroleptic uas tawm ntawm tag nrho lwm qhov atypical antipsychotics vim muaj kev sib txawv ntawm kev ua.
Cas Aripiprazole Txawv los ntawm Lwm Yam Atypicals?
Feem ntau cov atypical antipsychotics muaj cov nyhuv tseeb ntawm lub paj hlwb serotonin receptors tab sis ib qho kev tsis muaj zog thiab txwv tsis pub siv rau hauv lub paj hlwb dopamine receptors.
Aripiprazole yog txawv dua li lwm lub atypicals nrog regards rau nws mechanism ntawm kev txiav txim. Hauv essence, aripiprazole ua haujlwm ntawm dopamine. Yog li, los ntawm qhov pom ntawm nws ua haujlwm, aripiprazole yog ze rau lub cev los yog thawj tiam neeg neuroleptics, uas sib koom nris ntawm dopamine nyob rau hauv lub hlwb (thiaj li hu ua dopamine antagonism) raws li ib qho kev tawm tswv yim ntawm kev ua.
Yog Aripiprazole Ua Haujlwm rau Dopamine Vim li cas nws ho muab cais ua ib lub npe Atipical?
Yog vim li cas nws thiaj li muaj cov tshuaj pleev ploj (Articipse): nws txoj kev pheej hmoo rau qee yam kev nyuab siab txog kev nyuab siab xws li mob lub cev nqaij tawv (dystonia) lossis tsis txawv txav tsis zoo (dyskinesia) yog tsawg, uas khwv tau nws ua qhov atypical; as opposed to antipsychotics nrog ib qho kev pheej hmoo siab rau hom tshuaj muaj txiaj ntsim, uas yog cais ua cov raug.
Aripiprazole yog dopamine ib nrab agonist - as opposed to ib tug dopamine antagonist lossis blocker xws li feem ntau thawj tiam tshuaj antipsychotics.
Dopamine kev sib txuas lus yog dab tsi?
Dopamine yog ib qho ntawm cov neurotransmitters pom nyob rau theem ntawm qhov chaw hauv chaw synaptic, qhov chaw nyob rau hauv-ntawm neurons. Dopamine tso tawm rau hauv qhov chaw ntawm cov hlwv ntawm cov hlwv muaj nyob rau hauv pre-synaptic neuron, ces khi rau dopamine receptors nyob rau theem ntawm cov qog postsynaptic neuron.
Xav tias qhov no yog qhov tseem ceeb thiab xauv lub hom phiaj uas qhov dopamine receptors yog cov xauv uas qhib thaum lub dopamine "key" nkag mus rau hauv lub ntsuas phoo. Ib qho ntawm cov kev ntsuam xyuas ntawm schizophrenia yog tias nyob rau qee qhov ntawm lub paj hlwb muaj ntau cov dopamine nyob hauv lub zeem muag. Cov kev mob tshwm sim ntawm tus mob schizophrenia yog xav tau los ntawm tag nrho cov "dopamine" molecules ntxiv rau dopamine receptors. Dopamine antagonists khi rau dopamine receptors, li no thaiv dopamine losis tswvyim dabtsi. Thiab tsis muaj lub ntsiab tseem ceeb, piv txwv li, dopamine, lub xauv tsis qhib - ua lwm yam lus, raws li qhov teeb meem ntau qhov teeb meem yog kho ntawm theem ntawm cov synapse tsis muaj kev mob tshwm sim (cov tsos mob zoo) ntawm nws. Qhov teeb meem ho yog tias dopamine blockade tshwm sim tag nrho lub hlwb thaum lub dopamine ntau heev nyob rau hauv schizophrenia tsuas yog qee qhov tshwj xeeb ntawm lub hlwb. Tsis tas li ntawd, nyob rau hauv schizophrenia, thaum qee qhov chaw ntawm lub hlwb raug rau dopamine ntau heev, lwm qhov chaw yog qhov tseeb muaj dopamine nyiaj tsawg. Dopamine antagonists tsis tsuas yog thaiv cov chaw txais tos nyob rau hauv qhov chaw muaj ntau dhau ntawm nws tab sis kuj nyob rau hauv qhov chaw uas tsis muaj cov dopamine txaus. Qhov no yog vim li cov tshuaj no, thaum siv cov kev mob tshwm sim - vim kev tiv thaiv ntawm cov neeg nyob hauv hlwb hlwb vim muaj ntau dua dopamine, yuav zoo rau cov tsos mob tsis zoo , cov teeb meem kev xav, thiab qhov kev pheej hmoo rau parkinsonism hauv cov neeg mob lawv, ntawm dopamine hauv hlwb regions qhov muaj tsawg tus dopamine.
Ib qho kev daws teeb meem rau qhov teeb meem no yog siv ib nrab agonists.
Diali Dopamine Agonist yog dab tsi?
Dopamine ib nrab agonist yog ib qho molecule uas khi rau tus neeg tau txais kev pab thiab cov activates nws. Xav txog nws yog ib qho tseem ceeb uas haum rau hauv lub xauv kom lub qhov rooj tuaj yeem piav meej txog tab sis tsis qhib kiag li. Cov nyhuv ntawm ib nrab ntawm dopamine agonist yog tsawg tshaj li cov nyhuv ntawm dopamine, tiam sis ntau tshaj li qhov tsis muaj txhij txhua, uas yog dab tsi tshwm sim thaum ib tus neeg tau txais kev pab cuam tag. Hauv lwm lo lus, ib feem ntawm ib nrab. Qhov cov nyhuv ib nrab no txhais tau hais tias thaum muaj ntau qhov dopamine ncig aripiprazole (ib feem ntawm dopamine agonist) los ntawm kev noj cov dopamine chaw nyob rau hauv receptors thiab activating lawv tsuas yog cov yuav tau siv cov nyhuv ntawm ntau cov dopamine.
Nws kuj txhais tau hais tias thaum muaj me ntsis dopamine ncig mus qhib tag nrho cov neeg nyob hauv receptors aripiprazole yuav tau khi rau unoccupied receptors thiab nws cov nyhuv, txawm tias tsuas yog ib nrab, tam sim no ntxiv rau cov nyhuv dopamine hauv lub synapse rau net nce ntawm lub dopaminergic nyhuv ntawm dopamine-deprived synapse.
Los saib lub ntsiab lus, aripiprazole, raws li ib feem ntawm dopamine agonist, ua raws li ib tug modulator ntawm dopamine los. Thaum tam sim no, nws diminishes cov teebmeem ntawm ob qho tib si dopamine (los ntawm kev txo dopamine nkaus thaum nws muaj ntau dhau) thiab khaus (los ntawm kev ua dopamine kawg thaum nws muaj tsawg dhau ntawm nws).
Nyeem ntxiv
Arvid Carlsson: Ib qho dopaminergic sis tshaj tawm ntawm schizophrenia: txoj kev mus tshawb nrhiav. Dialogues Clin Neurosci. Peb Hlis 2006; 8 (1): 137-142