Cov Haus Luam Yeeb Kom Muaj Cov Phev Suav Tag Nrho
Tus cwj pwm marijuana siv ntau ntawm cov txiv neej ntawm cov hnub nyoog deev tsis tau muaj dua, thaum txiv neej yam kis tau ntxiv tseem nyob ntawm kev nce. Cov neeg tshawb nrhiav ntseeg hais tias kev sib kis ntawm kev kho mob kev cai lij choj thiab kev siv tshuaj yeeb dawb siv hauv Teb Chaws Asmeskas yuav yog qhov zoo tshaj plaws hauv kev nce hauv cov txiv neej ntxiv lawm.
Ob peb cov kev tshawb fawb tau txuas yeeb tshuaj xas thiab txiv neej ntxiv lawm tiam sis yuav ua li cas siv cov tshuaj muaj feem cuam tshuam ntxiv lawm tshe tau raug vim muaj ntau yam.
Ib txoj kev tshawb nrhiav tau pom tias cov txiv neej uas haus yeeb tshuaj xas feem ntau muaj tsawg tus seminal fluid, muaj pes tsawg tus phev suav thiab lawv cov phev coj txawv txav. Tag nrho cov teeb meem no yuav ua rau muaj kev cuam tshuam rau kev sib txig sib luag.
Lub University ntawm Buffalo txoj kev tshawb no yog thawj zaug mus tshuaj marijuana qhov teebmeem ntawm kev coj tus cwj pwm luam yeeb ntawm cov phev los ntawm marijuana haus luam yeeb thiab los sib piv nrog cov phev los ntawm cov txiv neej nrog paub meej tias fertility. Txiv neej muaj cov tshuaj Cannabinoid THC (tetrahydrocannabinol), nws thawj cov tshuaj psychoactive, thiab lwm cov kab mob cannabinoids.
Phev Ua Ntej Dej Yav Taw, Yav Dhau Los
"Cov kab hauv qab yog, cov khoom xyaw rau hauv marijuana ua haujlwm ua ib yam dab tsi rau cov phev, thiab cov zauv nyob rau hauv cov kev taw qhia txog kev mob ntxiv," said Lani J. Burkman, Ph.D., ua tus sau rau txoj kev tshawb no.
"Peb tsis paub xyov yog qhov hloov qhov phev ua haujlwm," hais tias Burkman, "tab sis peb xav tias nws yog ib yam ntawm ob yam: THC tej zaum yuav ua rau lub sijhawm tsis ua haujlwm ntawm kev ua phev los ntawm kev ua kom ncaj, lossis nws yuav ua rau kev poob siab mechanisms.
Xijpeem qhov ua rau, cov phev ua luam dej dhau sai dhau lawm. "
Hloov hauv Phev Enzyme Cap
Qhov no aberrant qauv tau txuas rau infertility rau lwm cov kev tshawb fawb, nws said.
Txoj kev tshawb no nkaws kuj pom nyob rau hauv qhov kev tshawb nrhiav andrology pom tias tib neeg phev raug rau cov qib siab ntawm THC cov kev hloov txawv txav hauv phev enzyme cap, hu ua acrosome.
Thaum cov neeg ntiav neeg tshawb xyuas tau kuaj cov khoom sib hlav hluavtaws sib txawv - ib qho tseem ceeb ntawm cov roj ntsha kua qaub - cov phev tib neeg, cov qauv ua luam dej yeej hloov thiab cov phev muaj peev xwm txo tus kabmob mus rau lub qe ua ntej fertilization.
Kev Xeem rau Cov Phev Suav
Burkman thiab cov npoj yaig tau txais lub ncauj ke ntu nruab nrab ntawm 22 tus kab mob haus luam yeeb ntawm cov neeg haus luam yeeb thiab tau soj ntsuam cov kev kuaj mus rau ntau hom kev xeem. Cov neeg tuaj yeem pab dawb qhia txog kev haus luam yeeb marijuana li ntawm 14 lub lim tiam, thiab qhov nruab nrab ntawm 5.1 xyoo.
Kev tswj cov naj npawb tau txais los ntawm 59 leej txiv neej uas tau tsim lub cev xeeb tub. Txhua tus txiv neej tsis nyiam los ntawm kev sib deev ua si rau ob hnub ua ntej qhov kev kuaj xyuas (lab).
Ntawm ob pawg, cov kev kuaj tau sim rau ntim, phev-suav-ib-unit ntawm seminal fluid, cov phev tag nrho, feem pua ntawm cov phev uas tau tsiv, tshaj tawm thiab phev puab.
Marijuana Smokers Yuav Tsawg Cov Phev
Cov txiaj ntsim tau pom tias ob lub ntim ntawm cov kua dej (seminal fluid) thiab tag nrho cov phev los ntawm marijuana cov neeg haus luam yeeb tau yau dua li cov txiv neej muaj peev xwm tswj tau. Cov kev sib txawv tseem ceeb tshwm sim nyob rau hauv thaum hyaluronic acid (ib qho anionic, nonsulfated glycosaminoglycan muab faib thoob plaws txhua lub hnab, lub hlwb, thiab lub hlwb) thiab kev tshaj tawm, ob qho tag nrho ua ntej thiab tom qab ntxuav, raug soj ntsuam, txoj kev tshawb pom pom.
"Cov phev los ntawm cov yeeb tshuaj marijuana tau txav dhau sai heev," hais tias Burkman. "Lub sij hawm poob txhua qhov tsis ncaj ncees lawm, Cov phev no yuav ua rau muaj kev kub ntxhov ua ntej lawv mus txog lub qe thiab tsis muaj peev xwm fertilization."
Risky rau Borderline Fertility Txiv neej
Cov neeg tshawb xyuas lees paub tias ntau tus txiv neej uas haus cawv luam yeeb tau muaj menyuam yaus. "Cov txiv neej uas muaj feem cuam tshuam feem ntau tau tshwm sim los ntawm borderline fertility, thiab THC los ntawm marijuana tej zaum yuav thawb lawv hla lub ploj mus ntxiv lawm," nws hais.
Raws li cov nqe lus nug ntawm seb puas muaj peev xwm rov qab tuaj thaum cov neeg haus luam yeeb tau siv cov yeeb tshuaj: Burkman tau hais tias qhov teeb meem tsis tau kawm zoo txaus los muab cov lus teb.
"THC tseem tshuav roj rau ntev ntev, yog li cov txheej txheem yuav qeeb qeeb, peb tsis paub tias txhua yam yuav rov qab mus rau qhov qub, feem ntau cov txiv neej uas muaj cov kabmob ciam teb tsis paub txog qhov tseeb. Kuv yuav twv yuav raug hu kom leej twg tabtom xeeb tub tsis haus luam yeeb, thiab qhov ntawd yuav muaj xws li cov poj niam thiab cov txiv neej. "
Hla Cov Pib Tshawb Fertilization
Tom qab cov kev tshawb fawb los ntawm Burkman thiab cov neeg koom tes pom tias cov yeeb tshuaj yuav siv tau los ua kom cov yeeb tshuaj hauv cov txheej txheem uas coj mus rau thaum siv cov tshuaj fertilization. Kev siv tshuaj yeeb yuav cuam tshuam nrog arachidonylethanolamide (AEA) tam sim no nyob hauv tib neeg cov ntshav siab, cov kua nruab nrab hauv nruab nrab ntawm oviductal, thiab cov kua nplaum (follicular fluid).
Phev yog raug rau cov dej haus no thaum lawv tsiv tawm ntawm qhov chaw mos mus rau qhov chaw ntawm fertilization nyob rau hauv oviduct. Cov soj ntsuam ntawm pom tias AEA-signaling yuav tswj tau cov kab mob phev uas yuav tsum tau siv rau kev siv tshuaj tua kab mob rau tib neeg, thiab kev haus luam yeeb ntawm cov tshuaj maj yuav cuam tshuam cov txheej txheem no.
Kev cuam tshuam cov phev kev khiav haujlwm
Lwm cov kev tshawb pom tau tias cov yeeb tshuaj siv tau cuam tshuam tau qhov kev mob endocannabinoid (ECS), uas yog kev koom tes hauv kev tswj cov poj niam txiv neej. Muaj ntau hom vivo thiab cov kev tshawb fawb hauv vitro pom tias cov yeeb tshuaj yuav ua rau cov tshuaj hypothalamus-pituitary-gonadal sperm, spermatogenesis, thiab ntau yam kev phev.
Lwm txoj kev tshawb fawb ntawm endocannabinoid lawv pom tias cov yeeb tshuaj yuav pab tiv thaiv kev ua haujlwm ntawm FAAH (fatty acid amide hydrolase) uas lawv pom muaj lub luag haujlwm tseem ceeb hauv kev lag luam ntawm cov kev ua lag luam, uas yog lub luag hauj lwm hauv kev tswj ob peb kauj ruam ntawm phev biology.
Nws yog pom tseeb los ntawm cov kev tshawb fawb ntau uas cov yeeb tshuaj tshuaj siv tau ua ntau lub luag dej num rau cov txiv neej luam thiab tsis muaj leej twg ua kom cov fertility.
Qhov chaw:
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Lewis, SE li al. "Endocannabinoids, phev biology thiab tib neeg fertility." Pharmacological Research Lub Kaum Hlis 2006
Schuel, H, thiab al. "Cov pov thawj tias anandamide-signaling tswj cov neeg phev rau tib neeg yuav tsum tau rau fertilization." Molecular Luam thiab Kev Loj Hlob